The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Transformation of CD5-Negative Follicular Lymphoma into CD5-Positive Diffuse Large B-Cell Lymphoma: A Case Report

CD5- 소포림프종의 CD5+ 광범위큰B세포림프종으로 전환된 1예

  • Kim, Hyeong-Kug (Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine) ;
  • Cho, In-Sung (Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine) ;
  • Lee, Hye-Kyung (Department of Pathology, Eulji University Hospital, Eulji University School of Medicine) ;
  • Choi, Yong-Hun (Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine) ;
  • Cho, Seong-Min (Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine) ;
  • Moon, Hyun-Jin (Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine) ;
  • Lee, Jin-A (Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine)
  • 김형국 (을지대학교 의과대학 을지대학병원 혈액종양내과) ;
  • 조인성 (을지대학교 의과대학 을지대학병원 혈액종양내과) ;
  • 이혜경 (을지대학교 의과대학 을지대학병원 병리과) ;
  • 최용훈 (을지대학교 의과대학 을지대학병원 혈액종양내과) ;
  • 조성민 (을지대학교 의과대학 을지대학병원 혈액종양내과) ;
  • 문현진 (을지대학교 의과대학 을지대학병원 혈액종양내과) ;
  • 이진아 (을지대학교 의과대학 을지대학병원 혈액종양내과)
  • Published : 2012.08.01
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Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of aggressive lymphomas. Approximately 10% of DLBCL cases express CD5 as a surface antigen. CD5-positive DLBCL can occur as the de novo or secondary type. De novo CD5-positive DLBCL arises without previous lymphoproliferative disease, and secondary CD5-positive DLBCL may or may not manifest as Richter syndrome. The transformation of follicular lymphoma (FL) into DLBCL occurs in approximately one-third of all cases. The transformation of CD5-negative low-grade B-cell lymphoma to CD5-positive DLBCL is extremely rare. We report the clinical features of a rare case that presented with a transformation from CD5-negative FL to CD5-positive DLBL over 11 years. This is the second such case published in the English literature.

이차적인 CD5 양성 광범위큰B세포림프종에서의 적절한 임상적 치료에 대한 좀 더 많은 논의가 필요할 것으로 생각된다. 본 증례는 장기간의 치료 기간 동안 잦은 재발을 보이는 소포림프종에서 좀 더 나쁜 예후를 보이는 CD5 양성 광범위큰B세포림프종으로 전환된 환자에서 기존에 알려진 치료와는 다른 구제요법을 통해 성공적인 치료성적을 보였고 치료 후 완전 관해를 보였다는 점에서 의의가 있음을 보고 하는 바이다.

Keywords

References

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