The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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A Case of Primary Effusion Lymphoma in a Patient with Chronic Kidney Disease

만성 신질환 환자에서 발생한 원발성 삼출액 림프종 1예

  • Kim, Mi-Yeon (Department of Internal Medicine, Jeju National University School of Medicine) ;
  • Han, Sang-Hoon (Department of Internal Medicine, Jeju National University School of Medicine) ;
  • Yu, Jung-Re (Department of Internal Medicine, Jeju National University School of Medicine) ;
  • Jeong, Woo-Seong (Department of Internal Medicine, Jeju National University School of Medicine) ;
  • Kim, Hyun-Woo (Department of Internal Medicine, Jeju National University School of Medicine) ;
  • Lee, Jae-Chun (Department of Internal Medicine, Jeju National University School of Medicine) ;
  • Hyun, Chang-Lim (Department of Pathology, Jeju National University School of Medicine)
  • 김미연 (제주대학교 의학전문대학원 내과학교실) ;
  • 한상훈 (제주대학교 의학전문대학원 내과학교실) ;
  • 유정래 (제주대학교 의학전문대학원 내과학교실) ;
  • 정우성 (제주대학교 의학전문대학원 내과학교실) ;
  • 김현우 (제주대학교 의학전문대학원 내과학교실) ;
  • 이재천 (제주대학교 의학전문대학원 내과학교실) ;
  • 현창림 (제주대학교 의학전문대학원 병리학교실)
  • Published : 2012.09.01
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Abstract

Human herpes virus-8 (HHV-8)-negative primary effusion lymphoma (PEL) is frequently observed in patients with chronic liver disease. We describe herein a case of PEL in a patient with chronic kidney disease. A 59-year-old woman presented with dyspnea. The patient had a history of uncontrolled pleural effusion. The pleural effusion revealed a malignant cell-dominant exudate. Serological tests were negative for human immunodeficiency virus (HIV). Initial chest and abdomen computed tomography showed bilateral pleural effusion; however, no evidence of a tumor mass or lymph node enlargement was found. A malignant lymphoma of diffuse large B-cell type was confirmed by pleural fluid cytology. Immunohistochemical staining of malignant cells was negative for HHV-8. She was treated with rituximab and CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone) chemotherapy. We report a case of PEL in a patient with chronic kidney disease that may be a plausible predisposing factor for HHV-8-negative PEL.

저자들은 만성 신부전 환자에서 HHV-8 음성 원발성 삼출액 림프종 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

  1. Lim YJ, Kim TY, Choi IS, et al. Diffuse large B-cell lymphoma with germinal center B-cell phenotype mimicking primary effusion lymphoma. J Clin Oncol 2011;29:e271-e273. https://doi.org/10.1200/JCO.2010.32.5258
  2. Fujisawa S, Tanioka F, Matsuoka T, Ozawa T. CD5+ diffuse large B-cell lymphoma with c-myc/IgH rearrangement presenting as primary effusion lymphoma. Int J Hematol 2005;81:315-318. https://doi.org/10.1532/IJH97.04155
  3. Jung SH, Zang DY. A case of primary pleural effusion lymphoma. Korean J Hematol 2002;37:297-301.
  4. Kang SY, Park CJ, Huh JR, Kang YG, Lee YS, Chi HS. Three cases of primary effusion lymphoma. Korean J Hematol 2003;38:136-141.
  5. Adiguzel C, Bozkurt SU, Kaygusuz I, Uzay A, Tecimer T, Bayik M. Human herpes virus 8-unrelated primary effusion lymphoma-like lymphoma: report of a rare case and review of the literature. APMIS 2009;117:222-229. https://doi.org/10.1111/j.1600-0463.2008.00005.x
  6. Pack KM, Kim SW, Lee SD, et al. A case of primary effusion lymphoma. Korean J Med 2008;74:441-444.
  7. Brimo F, Michel RP, Khetani K, Auger M. Primary effusion lymphoma: a series of 4 cases and review of the literature with emphasis on cytomorphologic and immunocytochemical differential diagnosis. Cancer 2007;111:224-233. https://doi.org/10.1002/cncr.22691
  8. Basuthakur S, Sarkar A, Burman S, Dandale R. A rare case of pleural lymphoma. Lung India 2008;25:160-162. https://doi.org/10.4103/0970-2113.45283
  9. Kang SH, Choi JG, Kwon OS, et al. A case of chronic pyothorax-associated lymphoma. Korean J Med 2011;81: 116-120.
  10. Kim GY, Lee SO, Lee JH, et al. A case of primary pericardial effusion lymphoma. Korean J Med 2008;74: 102-106.

Cited by

  1. Primary age‐related EBV‐associated effusion‐based lymphoma successfully treated with rituximab and thoracentesis vol.9, pp.5, 2012, https://doi.org/10.1002/ccr3.3971