DOI QR코드

DOI QR Code

Subarachnoid Hemorrhage Mimicking Leakage of Contrast Media After Coronary Angiography

  • Oh, Min-Seok (Department of Cardiology, Heart Center, Chung-Ang University College of Medicine) ;
  • Kwon, Jee-Eun (Department of Cardiology, Heart Center, Chung-Ang University College of Medicine) ;
  • Kim, Kyung-Jun (Department of Cardiology, Heart Center, Chung-Ang University College of Medicine) ;
  • Jo, Joon-Hwan (Department of Cardiology, Heart Center, Chung-Ang University College of Medicine) ;
  • Min, Yun-Ju (Department of Cardiology, Heart Center, Chung-Ang University College of Medicine) ;
  • Byun, Jun-Soo (Department of Radiology, Chung-Ang University College of Medicine) ;
  • Kim, Kyung-Tae (Department of Neurosurgery, Chung-Ang University College of Medicine) ;
  • Kim, Sang-Wook (Department of Cardiology, Heart Center, Chung-Ang University College of Medicine) ;
  • Kim, Tae-Ho (Department of Cardiology, Heart Center, Chung-Ang University College of Medicine)
  • 발행 : 2012.03.31

초록

We report a patient who developed subarachnoid hemorrhage (SAH) just after coronary angiography (CAG) with non-ionic contrast media (CM) and minimal dose of heparin. The 55-year-old man had a history of acute ST elevation myocardial infarction that had been treated with primary percutaneous coronary intervention and was admitted for a follow-up CAG. The CAG was performed by the transradial approach, using 1000 U of unfractionated heparin for the luminal coating and 70 mL of iodixanol. At the end of CAG, he complained of nausea and rapidly became stuporous. Brain CT showed a diffusely increased Hounsfield unit (HU) in the cisternal space, similar to leakage of CM. The maximal HU was 65 in the cisternal space. No vascular malformations were detected on cerebral angiography. The patient partially recovered his mental status and motor weakness after 2 days. Two weeks later, subacute SAH was evident on magnetic resonance imaging. The patient was discharged after 28 days.

키워드

참고문헌

  1. Sobieraj-Teague M, Gallus AS, Eikelboom JW. The risk of iatrogenic bleeding in acute coronary syndromes and long-term mortality. Curr Opin Cardiol 2008;23:327-34. https://doi.org/10.1097/HCO.0b013e3283021c5b
  2. Kim DH, Lee SJ, Jeon U, et al. Spontaneous retroperitoneal hemorrhage and hemothorax after intravenous heparin treatment. Korean Circ J 2009;39:32-6. https://doi.org/10.4070/kcj.2009.39.1.32
  3. Melton LG, Muga KM, Gabriel DA. Effect of iodixanol on in vitro bleeding time. Acad Radiol 1996;3:407-11. https://doi.org/10.1016/S1076-6332(05)80674-9
  4. Sharp S, Stone J, Beach R. Contrast agent neurotoxicity presenting as subarachnoid hemorrhage. Neurology 1999;52:1503-5. https://doi.org/10.1212/WNL.52.7.1503
  5. Eikelboom JW, Mehta SR, Anand SS, Xie C, Fox KA, Yusuf S. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation 2006;114:774-82. https://doi.org/10.1161/CIRCULATIONAHA.106.612812
  6. Velden J, Milz P, Winkler F, Seelos K, Hamann GF. Nonionic contrast neurotoxicity after coronary angiography mimicking subarachnoid hemorrhage. Eur Neurol 2003;49:249-51. https://doi.org/10.1159/000070198
  7. Weaver JP, Fisher M. Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management. J Neurol Sci 1994;125:119-31. https://doi.org/10.1016/0022-510X(94)90024-8
  8. Chakeres DW, Bryan RN. Acute subarachnoid hemorrhage: in vitro comparison of magnetic resonance and computed tomography. AJNR Am J Neuroradiol 1986;7:223-8.
  9. Hayman LA, Pagani JJ, Kirkpatrick JB, Hinck VC. Pathophysiology of acute intracerebral and subarachnoid hemorrhage: applications to MR imaging. AJR Am J Roentgenol 1989;153:135-9. https://doi.org/10.2214/ajr.153.1.135
  10. Yoon W, Seo JJ, Kim JK, Cho KH, Park JG, Kang HK. Contrast enhancement and contrast extravasation on computed tomography after intra- arterial thrombolysis in patients with acute ischemic stroke. Stroke 2004;35:876-81. https://doi.org/10.1161/01.STR.0000120726.69501.74
  11. May EF, Ling GS, Geyer CA, Jabbari B. Contrast agent overdose causing brain retention of contrast, seizures and parkinsonism. Neurology 1993;43:836-8. https://doi.org/10.1212/WNL.43.4.836
  12. Torvik A, Walday P. Neurotoxicity of water-soluble contrast media. Acta Radiol Suppl 1995;399:221-9.
  13. Eckel TS, Breiter SN, Monsein LH. Subarachnoid contrast enhancement after spinal angiography mimicking diffuse subarachnoid hemorrhage. AJR Am J Roentgenol 1998;170:503-5. https://doi.org/10.2214/ajr.170.2.9456974
  14. Sticherling C, Berkefeld J, Auch-Schwelk W, Lanfermann H. Transient bilateral cortical blindness after coronary angiography. Lancet 1998; 351:570. https://doi.org/10.1016/S0140-6736(05)78557-3
  15. Culebras A, Kase CS, Masdeu JC, et al. Practice guidelines for the use of imaging in transient ischemic attacks and acute stroke: a report of the stroke council, American Heart Association. Stroke 1997;28: 1480-97. https://doi.org/10.1161/01.STR.28.7.1480
  16. Melton LG, Muga KM, Gabriel DA. Effect of contrast media on in vitro bleeding time: assessment by a hollow fiber instrument. Acad Radiol 1995;2:239-43. https://doi.org/10.1016/S1076-6332(05)80172-2
  17. Schwartz TH, Solomon RA. Perimesencephalic nonaneurysmal subarachnoid hemorrhage: review of the literature. Neurosurgery 1996; 39:433-40.
  18. Rinkel GJ, van Gijn J, Wijdicks EF. Subarachnoid hemorrhage without detectable aneurysm: a review of the causes. Stroke 1993;24:1403-9. https://doi.org/10.1161/01.STR.24.9.1403
  19. De Wispelaere JF, Trigaux JP, Van Beers B, Gillard C. Cortical and CSF hyperdensity after iodinated contrast medium overdose: CT findings. J Comput Assist Tomogr 1992;16:998-9. https://doi.org/10.1097/00004728-199211000-00035

피인용 문헌

  1. Acute ischemic stroke mimicking subarachnoid hemorrhage after coronary angioplasty vol.55, pp.3, 2012, https://doi.org/10.1515/rjim-2017-0013
  2. Subdural contrast extravasation after percutaneous coronary intervention mimicking acute subdural hematoma : A case report vol.100, pp.17, 2021, https://doi.org/10.1097/md.0000000000025583