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A Case of Chemical Pneumonitis Induced by Glutaraldehyde Aspiration

글루탈알데히드 흡인으로 인해 발생한 화학성 폐렴

  • Jang, Suk-Hyun (Department of Internal Medicine, Konyang University College of Medicine) ;
  • Park, Min-Ji (Department of Internal Medicine, Konyang University College of Medicine) ;
  • Cho, A-Reum (Department of Internal Medicine, Konyang University College of Medicine) ;
  • Lee, Mi-Young (Department of Internal Medicine, Konyang University College of Medicine) ;
  • Cho, Sung-Woo (Department of Internal Medicine, Konyang University College of Medicine) ;
  • Hwang, Won-Min (Department of Internal Medicine, Konyang University College of Medicine) ;
  • Yun, Sung-Ro (Department of Internal Medicine, Konyang University College of Medicine)
  • 장석현 (건양대학교 의과대학 내과학교실) ;
  • 박민지 (건양대학교 의과대학 내과학교실) ;
  • 조아름 (건양대학교 의과대학 내과학교실) ;
  • 이미영 (건양대학교 의과대학 내과학교실) ;
  • 조성우 (건양대학교 의과대학 내과학교실) ;
  • 황원민 (건양대학교 의과대학 내과학교실) ;
  • 윤성로 (건양대학교 의과대학 내과학교실)
  • Published : 2012.10.01

Abstract

Glutaraldehyde is a five-carbon dialdehyde with highly reactive chemical properties. It has bactericidal, sporicidal, and fungicidal activities and is used as a disinfectant to combat foot-and-mouth disease in Korea. To our knowledge, there are no reports of chemical pneumonitis caused by glutaraldehyde aspiration. Chemical pneumonitis is defined as lung irritation caused by substances toxic to the lungs. We treated a 71-year-old patient who had a dyspnea and hoarseness that worsened 7 h after ingesting three mouthfuls of 10% glutaraldehyde. Upon arrival at the emergency room, he had severe laryngeal swelling. A chest radiograph showed diffuse haziness of both lower-lung fields. Despite all our efforts at treatment, he died from chemical pneumonitis and its secondary complications.

글루탈알데히드는 노출된 양상과 정도에 따라 결막염, 피부염 등의 비교적 경증 질환부터 후두 부종에 의한 기도 폐쇄, 화학성 폐렴 및 폐부종, 부식성 식도염, 장 천공 등의 중증 질환까지 다양하게 일으킬 수 있다. 저자들은 71세 남성이 10% 글루탈알데히드 용액을 흡인한 후 발생한 중증 화학성 폐렴과 이차적으로 발생한 합병증으로 사망한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

  1. Ha JW, Lee SS, Eom KS, et al. A case of chemical pneumonitis caused by nitric acid fume inhalation. Tuberc Respir Dis 2004;56:670-676. https://doi.org/10.4046/trd.2004.56.6.670
  2. Lee CY, Choi SW, Kim Y, et al. A case of chemical pneumonitis induced by ingestion of hydrocarbon. Tuberc Respir Dis 2000;49:639-643. https://doi.org/10.4046/trd.2000.49.5.639
  3. Nam SO, Moon DS, Lee DS, et al. A case of chemical pneumonitis caused by acetic acid fume inhalation. Tuberc Respir Dis 1994;41:424-428.
  4. Anadol D, Ozçelik U, Kiper N, Göçmen A. Chemical pneumonia caused by glutaraldehyde. Pediatr Int 2001;43: 701-702. https://doi.org/10.1046/j.1442-200X.2001.01451.x
  5. Zissu D, Bonnet P, Binet S. Histopathological study in B6C3F1 mice chronically exposed by inhalation to glutaraldehyde. Toxicol Lett 1998;95:131-139.
  6. Ballantyne B, Jordan SL. Toxicological, medical and industrial hygiene aspects of glutaraldehyde with particular reference to its biocidal use in cold sterilization procedures. J Appl Toxicol 2001;21:131-151. https://doi.org/10.1002/jat.741
  7. Quirce S, Gomez M, Bombin C, Sastre J. Glutaraldehydeinduced asthma. Allergy 1999;54:1121-1122. https://doi.org/10.1034/j.1398-9995.1999.00388.x
  8. Jachuck SJ, Bound CL, Steel J, Blain PG. Occupational hazard in hospital staff exposed to 2 per cent glutaraldehyde in an endoscopy unit. J Soc Occup Med 1989;39:69-71. https://doi.org/10.1093/occmed/39.2.69
  9. Kim JS, Lynch DA. Imaging of nonmalignant occupational lung disease. J Thorac Imaging 2002;17:238-260. https://doi.org/10.1097/00005382-200210000-00002
  10. American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 7th ed. Cincinnati: American Conference of Governmental Industrial Hygienists, 2001.

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