The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Definition of Severe Refractory Asthma

중증난치성 천식의 정의

  • Cho, You-Sook (Department of Allergy and Clinical Immunology, Asan Medical Center, Ulsan University College of Medicine)
  • 조유숙 (울산대학교 의과대학 서울아산병원 알레르기내과)
  • Published : 2012.10.01
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Abstract

Severe refractory asthma is a group of asthmatic patients showing heterogeneous phenotypes with frequent exacerbations and progressive airway remodeling despite high levels of therapy. Studies of severe asthma is difficult not only because of diverse pathogenesis, difficulty in translating pre-clinical human and animal models to clinical trials, and absence of biomarkers that predict therapeutic efficacy but because of lack of consensus on precise definition and diagnostic criteria of severe asthma. Furthermore, the burden of severe asthma is considerably high, therefore, there has been an urgent need for researching strategies to overcome severe asthma. In conclusion, precise characterization, exact definition, and appropriate classification of severe asthma would be critical to improve management of this challenging disease and these efforts could help to develop novel therapeutic strategies.

Keywords

References

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