Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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A Study on the Safety of Bangpungtongsung-san in Rats

랫드에서 방풍통성산의 안전성 연구

  • Jung, Ko-Eun (Division of Pharmacology, School of Korean Medicine, Pusan National University) ;
  • Lee, Kyoung-Jin (Division of Pharmacology, School of Korean Medicine, Pusan National University) ;
  • Lee, Chul-Won (Institute of Marine BioTechnology, Pusan National University) ;
  • Kwak, In-Seok (Dept. of Biological Science, Sil-La University) ;
  • Lee, Jang-Cheon (Division of Pharmacology, School of Korean Medicine, Pusan National University) ;
  • An, Won-Gun (Division of Pharmacology, School of Korean Medicine, Pusan National University)
  • 정고은 (부산대학교 한의학전문대학원 약물의학부) ;
  • 이경진 (부산대학교 한의학전문대학원 약물의학부) ;
  • 이철원 (부산대학교 해양생물기술연구소) ;
  • 곽인석 (신라대학교 생물과학과) ;
  • 이장천 (부산대학교 한의학전문대학원 약물의학부) ;
  • 안원근 (부산대학교 한의학전문대학원 약물의학부)
  • Received : 2012.11.17
  • Accepted : 2012.11.27
  • Published : 2012.12.30
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Abstract

Objectives : This study was conducted to investigate the safety of Bangpungtongsung-san in rats. Methods : The safety of this prescription on acute toxicity was evaluated by single dose toxicity study. Rats were orally administrated in a single dose of 0 and 2,000 mg/kg(limited dose) Bangpungtongsung-san. There were 7 rats in each groups. All animals were sacrificed after 14 days of treatment. After single administration, mortality, clinical signs, and body weight changes were observed for 14 days. Three parameters(autopsy finding, clinical chemistry, and hematology) were tested on the last day. Results : In this study with rats, Bangpungtongsung-san treatment did not show any acute toxicity. No mortality was noted for 14 days of treatment. There were no adverse effects on clinical signs, body weight changes, and autopsy finding at all treatment groups. The clinical chemistry parameters attesting to liver and kidney functions as well as the hematological parameters were within the normal ranges. Conclusions : It is considered that $LD_{50}$ of Bangpungtongsung-san is over 2,000 mg/kg in oral administration by rats. This finding of the safety of Bangpungtongsung-san is expected to strengthen the position of this prescription as nontoxic medicine.

Keywords

References

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