Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Changes in Anti-inflammatory Effect of Pyungwi-san Decoction According to the Preservation Temperature and Period

평위산 전탕액의 보관 온도 및 기간에 따른 항염증 효능 비교

  • Ha, Hyekyung (Basic Herbal Medicine Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Shin, In-Sik (Basic Herbal Medicine Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Lim, Hye-Sun (Basic Herbal Medicine Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Jeon, Woo-Young (Basic Herbal Medicine Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Jung-Hoon (Basic Herbal Medicine Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Seo, Chang-Seob (Basic Herbal Medicine Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Shin, Hyeun-Kyoo (Basic Herbal Medicine Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
  • 하혜경 (한국한의학연구원 한약기초연구그룹) ;
  • 신인식 (한국한의학연구원 한약기초연구그룹) ;
  • 임혜선 (한국한의학연구원 한약기초연구그룹) ;
  • 전우영 (한국한의학연구원 한약기초연구그룹) ;
  • 김정훈 (한국한의학연구원 한약기초연구그룹) ;
  • 서창섭 (한국한의학연구원 한약기초연구그룹) ;
  • 신현규 (한국한의학연구원 한약기초연구그룹)
  • Received : 2012.10.08
  • Accepted : 2012.12.05
  • Published : 2012.12.30
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Abstract

Objectives : To provide the information of preservation method for herbal decoction, we evaluated the anti-inflammatory effects according to preservation temperature and period of Pyungwi-san (PWS, Ping wei-san) decoction. Methods : The anti-inflammatory activity of PWS was investigated by carrageenin-induced paw edema in SD rats. At 0 month, PWS extract was administrated 100, 300 and 1000 mg/kg/day orally for seven days prior to induction of edema. Edema was induced by subcutaneous injection of 1% carrageenin into the right hind paw. The paw volume was measured at 4 hr following carrageenin-induced paw edema in rats. At 6 and 12 months, PWS extracts according to preservation temperatures (room temperature, $4^{\circ}C$ and $-20^{\circ}C$) were administrated in rats and then carrageenin-induced paw edema volume was measured. Results : PWS showed inhibitory effect on carrageenin-induced paw edema in rats and the optimal dose was 1000 mg/kg/day at 0 month of storage. At 6 month of storage, PWS storaged at $4^{\circ}C$ and $-20^{\circ}C$ were inhibited paw edema but that storaged at room temperature was not reduced paw edema in rats. Conclusions : These results suggest that PWS decoction pouch has anti-inflammatory activities at both $4^{\circ}C$ and $-20^{\circ}C$ during 6 month storage.

Keywords

References

  1. 김호철. 한의신문(2010. 10. 30.). http://www. akomnews.com/subpage/search_detail.php?code =A001&uid=57903&page=/subpage/search.ph p&nowpage=1&search_word=한약파우치 &search_key=all&sadop_date=--&eadop_d ate=
  2. 식품의약품안전청. 고시 제2012-54호 의약품등 의안정성시험기준.
  3. 한의과대학 방제학 교수 공편저. 방제학. 영림사. 1999:486.
  4. Park SH, Kim JS, Ryu BH, Park DW, Ryu KW. A study on the effects of Pyungwee-san and compounding of medicine in Pyungwee-san on the movement of gastrointestinal smooth muscles, anticatharsis and central nervous system. J. Oriental Chr. Dis. 2000;6(1):184-96.
  5. Shin CH. Effects of Pyeong yoe san extract and Jo gi pyeong yoe san extract on the experimental gastric ulcer in rats. J. Const. Med. 1990;2(1):189-97.
  6. Chang IK, Heu IM. Experimental studies on the efficacy of Pyungwee-san, Hyangsapyungwee -san and Bulwhangumchungglsan. K. H. Univ. O. Med. J. 1990;13:427-61.
  7. Kim YK, Ryu BH, Park DW, Ryu KW. A study on the effects of Pyungwee-san in the movement of gastrointestinal smooth muscles, anticatharsis and central nervous system. K. H. Univ. O. Med. J. 1999;22(1):185-202.
  8. Lee JA, Ha H, Jung DY, Lee HY, Lee JK, Huang DS, Shin HK. Comparative study of 25 herbal formulas on anti-inflammatory effect. J. Orient. Obst. Gynecol. 2010;23(3):101-11.
  9. Son JY, Shin JW, Son CG. Stability study for herbal drug according to storage conditions and periods. J Korean Oriental Med. 2009;30(2): 127-32.
  10. Keum HK, Lee SI. A study on the effect changes of Dae Hwang Mo Nan Pi Tang due to the time elapse. Kor. J. Herbology. 1991; 5(1):83-98.
  11. Han KS, Chio YB, Lee YJ. A study on the degraded effect of decocted Sosihotang over a period. Kor. J. Herbology. 1998;13(2):7-12.
  12. Kil GJ, Lim DB, Lee YJ. A study on the degraded effect of decocted Yeonkyopaedogsan over a period. Kor. J. Herbology 1998;13(1): 173-86.
  13. Choi YB, Lim DB, Lee YJ. A study on the degraded effect of decocted Youngsunjetongeum over a period. Korean J. Orient. Med. 1998; 19(1):410-8.
  14. Kim WG, Choi YB, Lee YJ. A study on the degraded effect of decocted Injinhotang over a period. Kor. J. Herbology 1998;13(2):14-8.
  15. Yun SJ, Lee SI. Study of Jagyakgamchotang's effect change by time. Kor. J. Herbology 1992;6(1):29-34.
  16. Seo CS, Kim JH, Lim SH, Shin HK. Estimation of shelf-life by long-term storage test of Pyungwisan. Korean J Orintal Medical Prescription. 2011;19(1):183-94.
  17. Seo CS, Shin HK, Kin JH, Shin KS. Changes of principal components and microbial population in Pyungwi-san decoction according to the preservation temperature and period. J. Koran Oriental Med. 2011;32(5):41-9.
  18. US Department of health and human services, Food and Drug Administration, Center for drug evaluation and research. Guidance for industry on Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. 2005. (http://www.fda.gov/downloads/Drugs/Guidan ceComplianceRegulatoryInformation/Guidances /ucm078932.pdf)