Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Relationship Between Expression of Gastrokine 1 and Clinicopathological Characteristics in Gastric Cancer Patients

  • Xiao, Jiang-Wei (Department of General Surgery, the Affiliated Hospital of North Sichuan Medical College) ;
  • Chen, Jia-Hui (Nanchong Central Hospital, the Second Clinical Institute of North Sichuan Medical College) ;
  • Ren, Ming-Yang (Nanchong Central Hospital, the Second Clinical Institute of North Sichuan Medical College) ;
  • Tian, Xiao-Bing (Department of General Surgery, the Affiliated Hospital of North Sichuan Medical College) ;
  • Wang, Chong-Shu (Department of General Surgery, the Affiliated Hospital of North Sichuan Medical College)
  • Published : 2012.11.30
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Abstract

The aim of the study was to clarify the role of gastrokine 1 in the process of formation and development of gastric cancer. The expression of gastrokine 1 in gastric cancer and corresponding non-cancerous gastric tissues of 52 gastric cancer patients was assessed with the real-time fluorescence quantitative polymerase chain reaction (RT-PCR) and immunohistochemistry. We also analyzed the relationship between the expression level and clinicopathological characteristics. Gastrokine 1 gene and protein expression in gastric cancer tissues was in both cases significantly lower than in corresponding non-cancerous gastric tissues (both P<0.01), but no significant relationship was found with clinicopathological parameters including tumor location, depth of invasion, differentiation, lymph node metastasis, stage, gender, age and carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) level in peripheral blood preoperation of patients (P>0.05, respectively). Furthermore, gastrokine 1 gene expression was markedly lower in gastric cancer tissues of Helicobacter pylori (HP)-positive patients than negative ones (P<0.05). The result of the study showed that gastrokine 1 might play a significant role in the process of formation and development of gastric cancer as an anti-oncogene. Its effect might be weakened by HP infection.

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References

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