Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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PPAR-Gamma Pro12Ala Polymorphism and Gastric Cancer Risk in a Turkish Population

  • Canbay, Emel (National Peritoneal Organization to support Peritoneal Dissemination Treatment, Tokushukai Hospital) ;
  • Kurnaz, Ozlem (Istanbul University, Experimental Medicine and Research Institute (DETAE), Department of Molecular Medicine) ;
  • Canbay, Bahar (Cerrahpasa Medical Faculty, Istanbul University) ;
  • Bugra, Dursun (American Hospital, General Surgery Clinic) ;
  • Cakmakoglu, Bedia (Istanbul University, Experimental Medicine and Research Institute (DETAE), Department of Molecular Medicine) ;
  • Bulut, Turker (Istanbul University, Istanbul Medical Faculty, Department of General Surgery) ;
  • Yamaner, Sumer (Istanbul University, Istanbul Medical Faculty, Department of General Surgery) ;
  • Sokucu, Necmettin (Istanbul University, Istanbul Medical Faculty, Department of General Surgery) ;
  • Buyukuncu, Yilmaz (Istanbul University, Istanbul Medical Faculty, Department of General Surgery) ;
  • Yilmaz-Aydogan, Hulya (Istanbul University, Experimental Medicine and Research Institute (DETAE), Department of Molecular Medicine)
  • Published : 2012.11.30
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Abstract

Background: Peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$) is a ligand dependent transcription factor involved in various processes, including carcinogenesis. We aimed to investigate any possible association of the $PPAR{\gamma}$ Pro12Ala (rs1801282) polymorphism with risk of developing gastric cancer (GC). Patients and Methods: A hospital based case control study was designed covering 50 patients with GC and 120 healthy controls. The frequencies of $PPAR{\gamma}$ Pro12Ala (rs1801282) were determined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Results: The Ala12 allele of the $PPAR{\gamma}$ Pro12Ala G gene was associated with a 1.95 fold increased risk of GC development (p: 0.022; 95% CI: 1.58-2.40). Subgroup analyses showed that the same allele was also associated with metastasis (p: 0.000; OR:4.09; 95%CI:2.273-7.368) and differentiation (p: 0.004; OR:1.95; 95%CI:1.335-2.875) in patients with GC. Conclusion: This study suggests that the $PPAR{\gamma}$ Pro12Ala G (Ala12) allele might be associated with development, differentiation and metastatic process of GC in the Turkish population. Further studies conducted in larger study groups and in different ethnic populations will be needed to clarify the exact role of the $PPAR{\gamma}$ Pro12Ala polymorphism in GC.

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References

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