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Expression of HMGB1 and its Clinical Significance in T-cell Lymphoma

  • Mao, Xing-Jiang (Department of General Surgery, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Wang, Geng-Fu (Department of Anesthesiology, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Chen, Zhi-Jun (Department of General Surgery, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Wang, Li-Na (Operating Room, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Zhang, Jun-Biao (Department of Cardiology, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Wang, Hui-Ling (Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xinxiang Medical University)
  • 발행 : 2012.11.30

초록

Objectives: To evaluate the clinical significance of HMGB1 expression in T-cell lymphoma. Methods: Immunohistochemical staining for HMGB1 and survivin was performed with specimens from 120 cases of T-cell lymphoma and 40 cases of reactive lymphoid hyperplasia with antibodies against human HMGB1 and survivin. Results: The expression of HMGB1 and survivin was significantly higher in tissues of T-cell lymphoma than in reactive lymphoid hyperplasia. Positive expression of HMGB1 and survivin was observed in 63.7% (65/102) and 61.8% (63/102) of T-cell lymphoma cases, respectively. While was associated with gender, age, and tumor location, significant correlations with malignancy and clinical stage were observed. Spearman rank correlation analysis revealed that the expression of HMGB1 and survivin was positively correlated in T-cell lymphomas (P<0.01). Conclusions: Expression of HMGB1 and survivin in T-cell lymphomas is significantly associated with malignancy and clinical stage, but not with gender, age and tumor location. Elevated expression of HMGB1 may be an important biomarker for the development and progression of T-cell lymphoma.

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참고문헌

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피인용 문헌

  1. Expression of High Mobility Group Box - B1 (HMGB-1) and Matrix Metalloproteinase-9 (MMP-9) in Non-small Cell Lung Cancer (NSCLC) vol.15, pp.12, 2014, https://doi.org/10.7314/APJCP.2014.15.12.4865
  2. Knockdown of HMGB1 inhibits growth and invasion of gastric cancer cells through the NF-κB pathway in vitro and in vivo vol.44, pp.4, 2014, https://doi.org/10.3892/ijo.2014.2285
  3. HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and DNA damage repair vol.37, pp.1, 2018, https://doi.org/10.1186/s13046-018-0883-3