Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Expression of HMGB1 and its Clinical Significance in T-cell Lymphoma

  • Mao, Xing-Jiang (Department of General Surgery, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Wang, Geng-Fu (Department of Anesthesiology, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Chen, Zhi-Jun (Department of General Surgery, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Wang, Li-Na (Operating Room, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Zhang, Jun-Biao (Department of Cardiology, The First Affiliated Hospital of Xinxiang Medical University) ;
  • Wang, Hui-Ling (Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xinxiang Medical University)
  • Published : 2012.11.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: To evaluate the clinical significance of HMGB1 expression in T-cell lymphoma. Methods: Immunohistochemical staining for HMGB1 and survivin was performed with specimens from 120 cases of T-cell lymphoma and 40 cases of reactive lymphoid hyperplasia with antibodies against human HMGB1 and survivin. Results: The expression of HMGB1 and survivin was significantly higher in tissues of T-cell lymphoma than in reactive lymphoid hyperplasia. Positive expression of HMGB1 and survivin was observed in 63.7% (65/102) and 61.8% (63/102) of T-cell lymphoma cases, respectively. While was associated with gender, age, and tumor location, significant correlations with malignancy and clinical stage were observed. Spearman rank correlation analysis revealed that the expression of HMGB1 and survivin was positively correlated in T-cell lymphomas (P<0.01). Conclusions: Expression of HMGB1 and survivin in T-cell lymphomas is significantly associated with malignancy and clinical stage, but not with gender, age and tumor location. Elevated expression of HMGB1 may be an important biomarker for the development and progression of T-cell lymphoma.

Keywords

References

  1. Cheng BQ, Jia CQ, Liu CT, et al (2008). Serum high mobility group box chromosomal protein 1 is associated with clinicopathologic features in patients with hepatocellular carcinoma. Dig Liver Dis, 40, 446-52. https://doi.org/10.1016/j.dld.2007.11.024
  2. Chung HW, Lee SG, Kim H, et al (2009). Serum high mobility group box-1(HMGB1) is closely associated with the clinical and pathologic features of gastric cancer. J Transl Med, 7, 38. https://doi.org/10.1186/1479-5876-7-38
  3. Jube S, Rivera ZS, Bianchi ME, et al (2012). Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma. Cancer Res, 72, 3290-301. https://doi.org/10.1158/0008-5472.CAN-11-3481
  4. Kawasaki H, Altieri DC, Lu CD, et al (1998). Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer. Cancer Res, 58, 5071-4.
  5. Kuniyasu H, Oue N, Wakikawa A, et al (2002). Expression of receptors for advanced glycation end-products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer. J Pathol, 196, 163-70. https://doi.org/10.1002/path.1031
  6. Lu YH, Luo XG, Tao X, et al (2007). Survivin gene RNA interference induces apoptosis in human HL60 leukemia cell lines. Cancer Biother Radio Pharm, 22, 819-25. https://doi.org/10.1089/cbr.2007.0401
  7. Reis FR, Vasconcelos FC, Pereira DL, et al (2011). Survivin and P-glycoprotein are associated and highly expressed in late phase chronic myeloid leukemia. Oncol Rep, 26, 471-8.
  8. Tang D, Kang R, Cheh CW, et al (2010). HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene, 29, 5299-310. https://doi.org/10.1038/onc.2010.261
  9. Wang SY, Chen ZY (2009). High mobility group box-1 protein and cancer. Shanghai Medical Journnal, 32, 757-60.
  10. Wang H, Yang H, Tracey KJ, et al (2004). Extracellular role of HMGB1 in inflammation and sepsis. J Intern Med, 255, 320-31. https://doi.org/10.1111/j.1365-2796.2003.01302.x

Cited by

  1. Expression of High Mobility Group Box - B1 (HMGB-1) and Matrix Metalloproteinase-9 (MMP-9) in Non-small Cell Lung Cancer (NSCLC) vol.15, pp.12, 2014, https://doi.org/10.7314/APJCP.2014.15.12.4865
  2. Knockdown of HMGB1 inhibits growth and invasion of gastric cancer cells through the NF-κB pathway in vitro and in vivo vol.44, pp.4, 2014, https://doi.org/10.3892/ijo.2014.2285
  3. HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and DNA damage repair vol.37, pp.1, 2018, https://doi.org/10.1186/s13046-018-0883-3