Physical Therapy Korea (한국전문물리치료학회지)

Korean Research Society of Physical Therapy (한국전문물리치료학회)
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Comparison of the Effects of Familiar Exercise and Novel Exercise on the Motor Function in Rat of Intracerebral Hemorrhage

익숙한 운동과 새로운 운동이 뇌내 출혈 흰쥐의 운동기능에 미치는 효과 비교

  • Jang, Sang-Hun (Dept. of Rehabilitation Science, The Graduate School, Daegu University) ;
  • Hwang, Kyoung-Ok (Dept. of Physical Therapy, College of Rehabilitation Science, Daegu University) ;
  • Kim, Jin-Sang (Dept. of Physical Therapy, College of Rehabilitation Science, Daegu University)
  • 장상훈 (대구대학교 대학원 재활과학과) ;
  • 황경옥 (대구대학교 재활과학대학 물리치료학과) ;
  • 김진상 (대구대학교 재활과학대학 물리치료학과)
  • Received : 2012.07.30
  • Accepted : 2012.09.04
  • Published : 2012.09.17
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Abstract

The purpose of the present study was to investigate the effects of familiar exercise and novel exercise on motor function after intracerebral hemorrhage (ICH) in rats. The rats were subjected to a unilateral striatal ICH via collagenase infusion. The rats were randomly divided into the following three groups: the CON (control group; rested one week post-ICH), the FE (familiar exercise group; familiar exercise was performed two weeks after one-week post-ICH period), and NE (novel exercise group; novel exercise was performed two weeks after one-week post-ICH period). We measured neurological behavior using a ladder rung walking test and a beam walking test; we measured the level of nerve growth factor (NGF) using immunohistochemistry and western blot analysis. We performed a one-way ANOVA test to analyze the scores obtained from the neurological behavior tests and the differences of NGF protein levels among the three groups. In the present study, the FE group and the NE group showed significant improvement during the neurological behavior tests and in their expression of NGF protein level, as compared to the CON group. Especially, NE group more increase than FE group in neurological behavior tests, the expression of NGF on motor cortex. In conclusion, these results suggest that, after ICH, familiar exercise and novel exercise enhance motor function and, novel exercise is more effective than familiar exercise.

Keywords

References

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