The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
권호 표지
DOI QR코드

DOI QR Code

Absorption Evaluation of Enteric Coated Capsules Containing Omega 3 Fatty Acids

장용성 연질 캡슐 오메가3 지방산의 흡수율 평가

  • Received : 2012.11.10
  • Accepted : 2012.12.10
  • Published : 2012.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

We investigate the changes of fatty acids in blood for an evaluation of the effects of soft and enteric coated capsules containing omega 3 fatty acids. Fish oil, which contained 62.87 g/100 g of sum of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), was used as nutracueticals for omega 3 fatty acids. Lipid releasing amount in soft capsule was 70% in stomach condition. However, there was 10% of releasing amount of lipid observed in enteric coated capsule in stomach condition. In intestinal condition, 50% of lipid releasing amount in enteric coated capsule showed until 6 hr, but soft capsule until 90 min. EPA and DHA contents in soft capsule administration showed higher level than those in enteric coated capsule until 8 hr. However, the administration of enteric coated capsule showed higher level of EPA and DHA in blood after 8 hr. After 24 hr, mono-, poly-unsaturated and saturated fatty acids contents with enteric coated capsule showed higher level than those with soft capsule. The enteric coated capsule containing omega 3 fatty acids was expected to sustain omega 3 fatty acids.

본 연구에서는 혈액 내에서의 오메가-3 지방산의 함량 변화를 측정하여 연질 캡슐과 장용성 캡슐의 차이를 검토하였다. Fish oil 중의 EPA와 DHA의 총합의 함량이 62.87 g/100 g으로 대부분을 차지하고 있다. 연질 캡슐의 경우, 제 1시험액(위액)에서는 내부의 지방이 70% 용출된 반면, 장용성의 경우 10% 정도만이 용출되었다. 제 2액(소장액)에서도 6시간까지 50% 정도 용출되어 90분에 50%가 용출된 일반 연질 캡슐과 대조적이었다. 기존에 사용하였던 연질 캡슐의 EPA 및 DHA는 흡수 초기에 장용성 캡슐에 비하여 다소 높은 비율을 보인 반면, 8시간 이후 장용성 캡슐 섭취한 경우 EPA와 DHA의 혈액내 함량이 비율이 증가하는 경향을 보였다. 경구 투여 48시간 후 지방산 조성은 장용성 캡슐에서는 mono-, poly-unsaturated fatty acid 혈액 내의 함량이 다소 높은 경향을 보였으며, saturated fatty acid 함량 역시 다소 높은 경향을 보였다. EPA와 DHA의 함량은 혈액 내에서 각 지방 분획에서의 함량 차이를 정확하게 측정하기 힘들었다. 이상의 결과에 의하면 장용성 캡슐은 위장관을 통과하여 장에서 용출되는 특성 때문에 지속적인 효과를 기대할 수 있을 것으로 추정된다.

Keywords

References

  1. Belluzzi A, Brignola C, Campieri M, Camporesi EP, Gionchetti P, Rizzello F, Belloi C, De Simone G, Boschi S, Miglioli M. 1994. Effect of new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients. Digest Dis Sci 39:2589-2594 https://doi.org/10.1007/BF02087694
  2. Belluzzi A, Brignola C, Campieri M, Pera A, Boschi S, Miglioli M. 1996. Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease. New Engl J Med 334:1557-1560 https://doi.org/10.1056/NEJM199606133342401
  3. Booth NH, McDonald LE. 1988. Veterinary Pharmacology and Therapeutics. 6th. ed. Iowa State Univ. Press
  4. Fetterman F, Hussain MM. 2009. Therapeutic potential of n-3 polyunsaturated fatty acids in disease. Am J Health Syst Ph 66:1169-1179 https://doi.org/10.2146/ajhp080411
  5. Folch J, Lees M, Sloane-Stanley G. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509
  6. Guo HX, Heinamaki J, Yliruusi J. 2002. Diffusion of a freely water-soluble drug in aqueous enteric-coated pellets. AAPS Pharm Sci Tech 3:97-104 https://doi.org/10.1208/pt030216
  7. Kim DK, Shin JA, Lee KT. 2011. Monitoring of compositions of gamma-linolenic acid and omega-3 fatty acids in some functionl foods consumed in market. CNU J Agric Sci 38:277-284
  8. Kim MC, Park JO, Kim NJ. 1994. Disintegration test of enteric coated capsules using radiopaque material in dogs. Korean J Vet Clin Med 11:377-381
  9. Ko WH, Hong JK, Lee SW, Cha JH, Baek HH, Park HJ. 2012. The effects of coating treatments on enteric coating of the soft capsules containing omega-3 fatty acids. Korean J Food Sci Technol 44:168-172 https://doi.org/10.9721/KJFST.2012.44.2.168
  10. Kosaraju SL. 2005. Colon targeted delivery systems: Review of polysaccharides for encapsulation and delivery. Crit Rev Food Sci Nutr 45:251-258 https://doi.org/10.1080/10408690490478091
  11. Kwrowska EM, Dresser GK, Deutsch L, Vachon D, Khalil W. 2003. Bioavailability of omega-3 essential fatty acids from perilla seed oil. Prostag Leukotr Ess 68:207-212 https://doi.org/10.1016/S0952-3278(02)00271-5
  12. Mose AJ. 1993. Gastroretentive dosage forms. Crit Rev Ther Drug Carrier Syst 10:143-195
  13. Park JS. 2011. Maternal and paternal nutrition before conception. J Korean Med Assoc 54:818-824 https://doi.org/10.5124/jkma.2011.54.8.818
  14. Park Y. 2010. Omega-3 index as a risk factor for cardiovascular disease and its application to Korean population. Korean J Obes 19:1-8
  15. Shargel YU. 1993. Physiologic Factors related to Drug Absorption. In: Applied Biopharmceutics and Pharmacokinetics. Prentice Hall, pp. 119-122
  16. Slover H, Lanza, E. 1979. Quantitative analysis of food fatty acids by capillary gas chromatography. J Am Oil Chem Soc 56:933-943 https://doi.org/10.1007/BF02674138