Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Association Between the XRCC3 T241M Polymorphism and Head and Neck Cancer Susceptibility: a Meta-analysis of Case-control Studies

  • Yin, Qing-Hua (Yueyang Second People's Hospital) ;
  • Liu, Chuan (Department of Oncology, Changhai Hospital, the Second Military Medical University) ;
  • Li, Lian (Yueyang Second People's Hospital) ;
  • Zu, Xu-Yu (The First Affiliated Hospital of University of South China) ;
  • Wang, Ya-Jie (Department of Oncology, Changhai Hospital, Second Military Medical University)
  • Published : 2012.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

Background: To evaluate the role of the X-ray repair cross complementing group 3 (XRCC3) T241M polymorphism in head and neck cancer susceptibility. Materials and Methods: We performed a meta-analysis of all available studies, which included 3,191 cases and 5,090 controls. Results: Overall, a significant risk effect of the T241M polymorphism was not found under homologous contrast (MM vs TT: OR=1.293, 95% CI=0.926-1.805; TM vs TT: OR=1.148 95% CI=0.930-1.418) and recessive models (MM vs TT+TM): OR=1.170, 95% CI=0.905-1.512, but a significantly increased risk was observed under a dominant model (MM+TM vs TT): OR=1.243, 95% CI=1.001-1.544. In stratified analyses, there were no significant associations for Asians or Caucasians. Conclusion: Our meta-analysis suggested the XRCC3 241M allele (MM+TM) might act as a head and neck cancer risk factor among all subjects, and the effect of T241M polymorphism on head and neck susceptibility should be studied with a larger, stratified population.

Keywords

References

  1. Ades AE, Lu G, Higgins JP (2005). The interpretation of randomeffects meta-analysis in decision models. Med Decis Making, 25, 646-54. https://doi.org/10.1177/0272989X05282643
  2. Al-Hadyan KS, Al-Harbi NM, Al-Qahtani SS, et al (2012). Involvement of single-nucleotide polymorphisms in predisposition to head and neck cancer in Saudi Arabia. Genet Test Mol Biomarkers,16, 95-101. https://doi.org/10.1089/gtmb.2011.0126
  3. Araujo FD, Pierce AJ, Stark JM, et al (2002). Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks. Oncogene, 21, 4176-80. https://doi.org/10.1038/sj.onc.1205539
  4. Benhamou S, Tuimala J, Bouchardy C, et al (2004). DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract. Int J Cancer, 112, 901-4. https://doi.org/10.1002/ijc.20474
  5. Bishop DK, Ear U, Bhattacharyya A, et al (1998). XRCC3 is required for assembly of Rad51 complexes in vivo. J Biol Chem, 273, 21482-8. https://doi.org/10.1074/jbc.273.34.21482
  6. Brenneman MA, Weiss AE, Nickoloff JA, et al (2000). XRCC3 is required for efficient repair of chromosome breaks by homologous recombination. Mutat Res, 459, 89-97. https://doi.org/10.1016/S0921-8777(00)00002-1
  7. Chuang SC, Jenab M, Heck JE, et al (2012). Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium. Cancer Causes Control, 23, 69-88.
  8. Cochran WG (1954). The combination of estimates from different experiments. Biometrics, 10, 101-29. https://doi.org/10.2307/3001666
  9. DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  10. Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. Br Med J, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  11. Gugatschka M, Dehchamani D, Wascher TC, et al (2011). DNA repair gene ERCC2 polymorphisms and risk of squamous cell carcinoma of the head and neck. Exp Mol Pathol, 91, 331-4. https://doi.org/10.1016/j.yexmp.2011.03.004
  12. Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539-58. https://doi.org/10.1002/sim.1186
  13. Huang WY, Olshan AF, Schwartz SM, et al (2005). Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysis. Cancer Epidemiol Biomarkers Prev, 14, 1747-53. https://doi.org/10.1158/1055-9965.EPI-05-0162
  14. Kamangar F, Dores GM, Anderson WF (2006). Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol, 24, 2137-50. https://doi.org/10.1200/JCO.2005.05.2308
  15. Kostrzewska-Poczekaj M, Gawęcki W, Illmer J, et al (2012). Polymorphisms of DNA repair genes and risk of squamous cell carcinoma of the head and neck in young adults. Eur Arch Otorhinolaryngol, 2012. [Epub ahead of print]
  16. Kietthubthew S, Wickliffe J, Sriplung H, et al (2006). Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand. Int J Hyg Environ Health, 209, 21-9. https://doi.org/10.1016/j.ijheh.2005.06.002
  17. Kietthubthew S, Wickliffe J, Sriplung H, et al (2010). Association of polymorphisms in proinflammatory cytokine genes with the development of oral cancer in Southern Thailand. Int J Hyg Environ Health, 213, 146-52. https://doi.org/10.1016/j.ijheh.2010.01.002
  18. Majumder M, Sikdar N, Paul RR, et al (2005). Increased risk of oral leukoplakia and cancer among mixed tobacco users carrying XRCC1 variant haplotypes and cancer among smokers carrying two risk genotypes: one on each of two loci, GSTM3 and XRCC1 (Codon 280). Cancer Epidemiol Biomarkers Prev,14, 2106-12. https://doi.org/10.1158/1055-9965.EPI-05-0108
  19. Matullo G, Dunning AM, Guarrera S, et al (2006). DNA repair polymorphisms and cancer risk in non-smokers in a cohort study. Carcinogenesis, 27, 997-1007. https://doi.org/10.1093/carcin/bgi280
  20. Nicolotti N, Chuang SC, Cadoni G, et al (2011). Recreational physical activity and risk of head and neck cancer: a pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium. Eur J Epidemiol, 26, 619-28. https://doi.org/10.1007/s10654-011-9612-3
  21. Parkin DM, Bray F, Ferlay J, et al (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  22. Pierce AJ, Johnson RD, Thompson LH, et al (1999). XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev, 13, 2633-8. https://doi.org/10.1101/gad.13.20.2633
  23. Rydzanicz M, Wierzbicka M, Gajecka M, et al (2005). The impact of genetic factors on the incidence of multiple primary tumors (MPT) of the head and neck. Cancer Lett, 224, 263-78. https://doi.org/10.1016/j.canlet.2005.01.015
  24. Schottenfeld D, Fraumeni JF (2006). Cancer Epidemiology and Prevention, 3rd edn. Oxford University Press, New York 2006.
  25. Shen H, Sturgis EM, Dahlstrom KR, et al (2002). A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis. Int J Cancer, 99, 869-72. https://doi.org/10.1002/ijc.10413
  26. Sliwinski T, Walczak A, Przybylowska K, et al (2010). Polymorphisms of the XRCC3 C722T and the RAD51 G135C genes and the risk of head and neck cancer in a Polish population. Exp Mol Pathol, 89, 358-66. https://doi.org/10.1016/j.yexmp.2010.08.005
  27. Stott-Miller M, Chen C, Chuang SC, et al (2012). History of diabetes and risk of head and neck cancer: a pooled analysis from the international head and neck cancer epidemiology consortium. Cancer Epidemiol Biomarkers Prev, 21, 294-304. https://doi.org/10.1158/1055-9965.EPI-11-0590
  28. Szymanska K, Levi JE, Menezes A, et al (2010). TP53 and EGFR mutations in combination with lifestyle risk factors in tumours of the upper aerodigestive tract from South America. Carcinogenesis, 31, 1054-9. https://doi.org/10.1093/carcin/bgp212
  29. Tebbs RS, Zhao Y, Tucker JD, et al (1995). Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of theXRCC3 DNA repair gene. Proc Natl Acad Sci USA, 92, 6354-8. https://doi.org/10.1073/pnas.92.14.6354
  30. Werbrouck J, De Ruyck K, Duprez F, et al (2008). Single-nucleotide polymorphisms in DNA double-strand break repair genes: association with head and neck cancer and interaction with tobacco use and alcohol consumption. Mutat Res, 656, 74-81. https://doi.org/10.1016/j.mrgentox.2008.07.013
  31. Wen SX, Zhang XM, Tang PZ, et al (2007). Association between genetic polymorphism in DNA repair genes XRCC3 and risks of laryngeal and hypopharyngeal carcinomas. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 42, 856-9.
  32. Yen CY, Liu SY, Chen CH, et al (2008). Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan. J Oral Pathol Med, 37, 271-7.

Cited by

  1. XRCC3 T241M polymorphism is associated risk of hepatocellular carcinoma in the Chinese vol.34, pp.4, 2013, https://doi.org/10.1007/s13277-013-0765-4
  2. Association between the XRCC3 Thr241Met Polymorphism and Breast Cancer Risk: an Updated Meta-analysis of 36 Case-control Studies vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6613
  3. Quantitative assessment of the associations between DNA repair gene XRCC3 Thr241Met polymorphism and gastric cancer vol.35, pp.2, 2014, https://doi.org/10.1007/s13277-013-1219-8
  4. XRCC3 Thr241Met polymorphism and ovarian cancer risk: a meta-analysis vol.35, pp.3, 2014, https://doi.org/10.1007/s13277-013-1357-z
  5. Lack of Influence of an XRCC3 Gene Polymorphism on Oral Cancer Susceptibility: Meta-analysis vol.15, pp.23, 2015, https://doi.org/10.7314/APJCP.2014.15.23.10329
  6. Association of RAD 51 135 G/C, 172 G/T and XRCC3 Thr241Met Gene Polymorphisms with Increased Risk of Head and Neck Cancer vol.15, pp.23, 2015, https://doi.org/10.7314/APJCP.2014.15.23.10457
  7. DNA repair gene XRCC3 Thr241Met polymorphism and susceptibility to glioma: A case-control study vol.8, pp.2, 2014, https://doi.org/10.3892/ol.2014.2192