Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Effect of Mirtazapine on MNNG-Induced Gastric Adenocarcinoma in Rats

  • Bilici, Mehmet (Ataturk University, Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology) ;
  • Cayir, Kerim (Ataturk University, Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology) ;
  • Tekin, Salim Basol (Ataturk University, Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology) ;
  • Gundogdu, Cemal (Ataturk University, Faculty of Medicine, Department of Pathology) ;
  • Albayrak, Abdulmecit (Ataturk University, Faculty of Medicine, Department of Pharmacology) ;
  • Suleyman, Bahadir (Ataturk University, Faculty of Medicine, Department of Pharmacology) ;
  • Ozogul, Bunyamin (Ataturk University, Faculty of Medicine, Department of General Surgery) ;
  • Erdemci, Burak (Ataturk University, Faculty of Medicine, Department of Radiation Oncology) ;
  • Suleyman, Halis (Ataturk University, Faculty of Medicine, Department of Pharmacology)
  • Published : 2012.10.31
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Abstract

Objective: In this study, anticancer effects of mirtazapine on rats were investigated in an adenocarcinoma model induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and compared with those of cisplatin. Materials and Methods: For this purpose, 10 mg/kg doses of mirtazapine were administered orally to one group of rats, while 1 mg/kg doses of cisplatin were administered intraperitoneally to another group. At 1 hour after administration, 200 mg/kg doses of MNNG were given orally to both groups. MNNG administration was repeated once every 10 days through 3 months, after which period, gastric tissue was taken and pathologically evaluated. Results: Mirtazapine prevented adenocarcinoma induction by MNNG in rats to a greater extent than cisplatin. Some of the rats receiving cisplatin demonstrated severe dysplasia in gastric samples and others exhibited mild dysplasia. Rats given mirtazapine were not observed to suffer severe dysplasia, only mild dysplasia being observed. Conclusion: For adenocarcinoma induced by MNNG on rats, mirtazapine was determined more effective than cisplatin. In order to make statement about mechanism of anticancer activity of mirtazapine, wider studies are required.

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References

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