Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Influence of Alcohol Consumption on Oxidative Stress and Antioxidant Status in Cancer Patients - Case-control Study from Western Nepal

  • Nagamma, T. (Department of biochemistry, Melaka Manipal Medical College) ;
  • Bhutia, Rinchen Doma (Department of Biochemistry, Sikkim Manipal Institute of Medical Sciences) ;
  • Pokharel, Daya Ram (Department of Physiology, Narayana Medical College) ;
  • Yadav, Saraswati (Department of biochemistry, Manipal College of Medical Sciences) ;
  • Baxi, J. (Department of Surgery, Manipal College of Medical Sciences)
  • Published : 2012.07.31
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Abstract

Aim: The present study assess the effect of consumption of alcohol on oxidative stress and antioxidant status in patients suffering from different types of cancer. Methods: This hospital based case control study conducted in the Western part of Nepal covered a total of 93 cancer patients with or without alcohol intake and smoking habits, along with 94 age, sex and habit-matched individuals serving as controls. Plasma thiobarbituric acid reacting substances (TBARS), total antioxidant activity (TAA), vitamin C, ${\alpha}$-tocopherol and erythrocyte reduced glutathione (GSH) were estimated and compared. Results: The TBARS level was found to be significantly higher ($p{\leq}0.001$) in all types of cancer patients when compared to controls, being aggravated in alcoholics with a smoking habit. No statistical significance ($p{\geq}0.05$) was observed in the level of vitamin C and ${\alpha}$-tocopherol. GSH and TAA level were significantly decreased ($p{\leq}0.001$) in all the groups except those who consumed both branded as well as homemade alcohol and non-alcoholics without smoking habit. Conclusion: Alcohol, irrespective of its commercial brand, increases oxidative stress in all types of cancer patients. This is even higher when alcohol intake is combined with a smoking habit. Decreased TAA and GSH are major risk factors for cancer development.

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References

  1. Adhikari D, Baxi J, Risal S, Singh PP (2005). Oxidative stress and antioxidant status in cancer patients and healthy subjects. Nepal Med Coll J, 7, 112-5.
  2. Baan R, Straif K, Grosse Y, et al (2007). On behalf of the WHO international agency for research on cancer monograph working group. Carcinogenicity of alcoholic beverages. Lancet oncol, 8, 292-3. https://doi.org/10.1016/S1470-2045(07)70099-2
  3. Baker H, Frank O (1968). Clinical Vitaminology, Methods and Interpretation, 4 Interscience Publishers, John Wiley and sons Incs, NewYork, 172.
  4. Benzie IFF, Strain JJ (1996). The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": The FRAP assay. Annal Biochem, 239, 70-6. https://doi.org/10.1006/abio.1996.0292
  5. Binu VS, Chandrashekhar TS, Subba SH, et al (2007). Cancer Pattern in Western Nepal: A Hospital Based Retrospective Study. Asian Pac J Cancer Prev, 8, 183-6.
  6. Buege JA, Aust SD (1978). The thiobarbituric acid assay. Methods enzymol, 523, 6-10.
  7. Buetler E, Kelly BM (1963). Improved method for the determination of blood glutathione. J Lab Clin Med, 61, 882.
  8. Ching S, Ingram D, Hahnel R, et al (2002). Serum levels of micronutrients, antioxidants and total antioxidant status predict risk of breast cancer in a case control study. J Nutr, 132, 303-6.
  9. Das SK, Vasudevan DM (2005). Biochemica diagnosis of alcoholism. Indian J Clin Biochem, 20, 35-42.
  10. Dey, Caderbaum AI (2006). Alcohol and liver injury. Hepatology, 43, 563-74. https://doi.org/10.1002/hep.21049
  11. Garavello W, Bosetti C, Gallus S, et al (2006). Type of alcoholic beverage and the risk of laryngeal cancer. Eur J Cancer Prev, 15, 69-73. https://doi.org/10.1097/01.cej.0000186641.19872.04
  12. Hamajima N, Hirose K, Tajima K, et al (2002). Collaborative group on hormonal factors in breast cancer. Alcohol, tobacco and breast cancer - collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer, 87, 1234-45. https://doi.org/10.1038/sj.bjc.6600596
  13. Ha HL, Shin HJ, Feitelson MA, Yu DY (2010). Oxidative stress and antioxidants in hepatic pathogenesis. World J Gastroenterol, 16, 6035-43. https://doi.org/10.3748/wjg.v16.i48.6035
  14. IARC (2010). Alcoholic beverage consumption and ethyl carbamate (urethane). IARC monographs on the evaluation of carcinogenic risks to humans vol. 96, International Agency for Research on Cancer, Lyon.
  15. Jedrychowski W, Steindorf K, Popiela T, et al (2001). Risk of colorectal cancer from alcohol consumption at lower vitamin intakes. A hospital based case- control study in Poland. Rev Environ Health, 16, 213-22.
  16. Jha JC, Maharjan BR, Adhikari D, et al (2007). Cigarette smoke induced oxidative insult in local population of Pokhara. Kathmandu Univ Med J, 5, 511-7.
  17. Kaplan LA, Pesce AJ (1996). Clinical chemistry. Theory, analysis and correlation; third edition, Mosby publication. pp: 683-92.
  18. Key J, Hodgson S, Omar RZ, et al (2006). Meta-analysis of studies of alcohol and breast cancer with consideration of the methodological issues. Cancer Causes Control, 17, 759-70. https://doi.org/10.1007/s10552-006-0011-0
  19. Kim YH, Shin MJ (2002). Effect of high taurocholate load on activities of hepatic alcohol metabolizing enzymes. Exp Mol Med, 34, 123-30. https://doi.org/10.1038/emm.2002.18
  20. Kumaraguruparan R, Subapriya R, Kabalimoorthy J, Nagini S (2002). Antioxidant profile in the circulation of patients with fibroadenoma and adenocarcinoma of the breast. Clin Biochem, 35, 275-9. https://doi.org/10.1016/S0009-9120(02)00310-7
  21. Lieber C S (2002). S-Adenosyl-L-methionine: its role in the treatment of liver disorders. Am J Clin Nutr, 76, 1183-7.
  22. Lu S C (2000). Regulation of glutathione synthesis. Curr Top Cell Regul, 36, 95-116.
  23. Manjunath MK, Annam V, Suresh DR (2010). Significance of free radical injury in laryngeal and hypopharyngeal cancers. J Laryngol Otol, 124, 315-7. https://doi.org/10.1017/S0022215109991721
  24. Mckillop LH, Schrum LW (2005). Alcohol and liver cancer. Alcohol, 35, 195-203. https://doi.org/10.1016/j.alcohol.2005.04.004
  25. Ming Wu, Jin K Z, Zuo F Z, et al (2011). Smoking and alcohol drinking increased the risk of esophagal cancer among Chinese men but not women in a high risk population. Cancer Causes Control, 22, 649-57. https://doi.org/10.1007/s10552-011-9737-4
  26. Natelson S (1971). Techniques of Clinical Chemistry, 3rd ed. Charles, C Thomas, USA, p.288.
  27. Nagamma.T, Anjaneyulu K, Baxi J, et al (2011). Effects of cigarette smoking on lipid peroxidation and antioxidant status in cancer patients from Western Nepal. Asian pac J Cancer Prev, 12, 313-6.
  28. Pradhananga K K, Baral M, Shrestha B M (2009). Multi-institution hospital-based cancer incidence data for Nepal - an initial report. Asian Pac J Cancer Prev, 10, 259-62.
  29. Poschl G, Seitz HK (2004). Alcohol, 39, 155-65. https://doi.org/10.1093/alcalc/agh057
  30. Pronko P, Bardina L, Satanovskaya V, et al (2002). Effect of alcohol on mebolizing systems in the rat gastrointestinal tract. Alcohol, 37, 229-35.
  31. Rainis T, Maor I, Lanir A, et al (2007). Enhanced oxidative stress and leucocyte activation in neoplastic tissues of the colon. Dig Dis Sci, 52, 526-30. https://doi.org/10.1007/s10620-006-9177-2
  32. Rehm J, Room R, Monteiro M, et al (2004). Alcohol Use. In: Ezatti M, Murray C, Lopez AD, Rodgers A (eds) Comparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors. World Health Organization, Geneva, 1, 959-1108.
  33. Risal S, Adhikari D, Alurkar VM, Singh PP (2006). Oxidative stress and antioxidant status in cardiovascular diseases in population of western Nepal. Kathmandu Univ Med J, 4, 271-4.
  34. Samir Z (2006). Overview: How is alcohol metabolized by the body? Alcohol Res health, 4, 245-54.
  35. Sener DE, Gonenc A, Akinci M, Torun M (2006). Lipid peroxidation and total antioxidant status in patients with breast cancer. Cell Biochem Funct, 25, 377-82.
  36. Sergent O, Griffon B, Cillard P, Cillard J (2001). Alcohol and oxidative stress. Pathol Biol (Paris), 49, 689-95. https://doi.org/10.1016/S0369-8114(01)00244-9
  37. Su LJ, Arab L (2004). Alcohol consumption and risk of colon cancer: evidence from the national health and nutrition examination survey I epidemiologic follow-up study. Nutrition and Cancer, 50, 111-9. https://doi.org/10.1207/s15327914nc5002_1
  38. Su H-X, Hao C-Y, Mi D-H, Zheng R-L (2001). 8-hydroxy-2'-deoxyguanosine of gastric mucosa DNA and the plasma total radical-trapping antioxidative capacity in patients with gastric adenocarcinoma and chronic gastritis. Chin Med J, 114, 42-57.
  39. Terry P, Suzuki R, Hu FB, Wolk A (2001). A prospective study of major dietary patterns and the risk of breast cancer. Can Epid Biol, 10, 1281-5.
  40. Tuma DJ (2002). Role of malondialdehyde- acetaldehyde adducts in liver injury. Free Rad Bio Med, 32, 303-8. https://doi.org/10.1016/S0891-5849(01)00742-0
  41. Vioque J, Barber X, Bolumar F, et al (2008). Esophageal cancer risk by type of alcohol drinking and smoking: a case-control study in Spain. BMC Cancer, 8, 1-10. https://doi.org/10.1186/1471-2407-8-1
  42. Voigt MD (2005). Alcohol in hepatocellular cancer. Clinic Liver Dis, 9, 151-69. https://doi.org/10.1016/j.cld.2004.10.003
  43. WHO (2011). Global status report on alcohol and health, p: 275.
  44. Worrall S, Thiele GM (2001). Protein modification in ethanol toxicity. Adverse Drug React Toxicol Reviews, 20,133-59.
  45. Wu A I (2003). Cederbaum, Alcohol, oxidative stress, and free radical damage. Alcohol Res Health, 27, 277-84.
  46. Zambon P, Talamini R, La Vecchia C, et al (2000). Smoking, type of alcoholic beverage and squamous - cell oesophageal cancer in northern Italy. Int J Cancer, 86, 144-9. https://doi.org/10.1002/(SICI)1097-0215(20000401)86:1<144::AID-IJC23>3.0.CO;2-B

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