Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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TERT rs2736098 Polymorphism and Cancer Risk: Results of a Meta-analysis

  • Qi, Hao-Yu (Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University) ;
  • Zou, Peng (Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University) ;
  • Zhao, Lin (Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University) ;
  • Zhu, Jue (Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University) ;
  • Gu, Ai-Hua (Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University)
  • Published : 2012.07.31
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Abstract

Objective: Several studies have demonstrated associations between the TERT rs2736098 single nucleotide polymorphisms (SNPs) and susceptibility to cancer development. However, there are conflicting results. A systematic meta-analysis was therefore performed to establish the cancer risk associated with the polymorphism. Methods: In this meta-analysis, a total of 6 case-control studies, including 5,567 cases and 6,191 controls, were included. Crude odds ratios with 95% confidence intervals were used to assess the strength of associations in several genetic models. Results: Our results showed no association reaching the level of statistical significance for overall risk. Interestingly, in the stratified analyses (subdivided by ethnicity), significantly increased risks were found in the Asian subgroup which indicates the TERT rs2736098 polymorphism may have controversial involvement in cancer susceptibility. Conclusions: Overall, this meta-analysis indicates that the TERT rs2736098 polymorphism may have little involvement in cancer susceptibility.

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References

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