Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Survival Rate and Prognostic Factors of Esophageal Cancer in East Azerbaijan Province, North-west of Iran

  • Mirinezhad, Seyed Kazem (Liver and Gastrointestinal Disease Research Center) ;
  • Somi, Mohammad Hossein (Liver and Gastrointestinal Disease Research Center) ;
  • Jangjoo, Amir Ghasemi (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
  • Seyednezhad, Farshad (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
  • Dastgiri, Saeed (School of Medicine and National Public Health Management Center) ;
  • Mohammadzadeh, Mohammad (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
  • Naseri, Ali Reza (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences) ;
  • Nasiri, Behnam (Radiation Oncology Therapy of IMAM REZA (AS) Hospital, Tabriz University of Medical Sciences)
  • Published : 2012.07.31
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Abstract

Background: Esophageal cancer in Iran is the sixth most common cancer and is particularly important in east Azerbaijan. The aim of this study was to calculate survival rates and define prognostic factors in esophageal cancer patients. Methods: In this study, all patients with esophageal cancer registered in the Radiation Therapy Center, during March 2006 to March 2011, were analyzed and followed up for vital status. Data were analyzed using the Kaplan-Meier method and the Cox proportional hazard models. Results: Out of 532 patients, survival information was available for 460, including 205 (44/ 5%) females and 255 (55/4%) males. The mean age was $65.8{\pm}12.2$, ranging from 29 to 90 years at the time of diagnosis. 1-, 3- and 5-year survival rates after diagnosis were 55%, 18% and 12%, respectively, with a median survival time of $13.2{\pm}.7$ (CI 95% =11.8-14.6) months. In the univariate analysis, age (P=0/001), education (P=0/001), smoking status (P= 0/001), surgery (P= 0/001), tumor differentiation (P= 0/003) and tumor stage (P= 0/001) were significant prognostic factors. Tumor morphology, sex, place of residence, tumor histology and tumor location did not show any significant effects on the survival rate. In multivariate analysis, age (P = 0/003), smoking (P= 0/01) and tumor stage (P= 0/001) were significant independent predictors of survival. Conclusion: In summary, prognosis of esophageal cancer in North West of Iran is poor. Therefore, reduction in exposure to risk factors and early detection should be emphasized to improve survival.

Keywords

References

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