Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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TNM Stages and Prognostic Features of Colorectal and Mucinous Adenocarcinoma Patients: a Meta Analysis

  • Chen, Jing-Xiang (Department of Emergency, Jiangjin Central Hospital) ;
  • Tang, Xu-Dong (Department of Gastroenterology, Daping Hospitail, Third Military Medical University) ;
  • Xiang, De-Bing (Department of Oncology, Jiangjin Central Hospital) ;
  • Dong, Xiao-Ling (Department of Hepatobiliary Surgery, Jiangjin Central Hospital) ;
  • Peng, Fang-Yi (Department of Clinical Laboratory, Jiangjin Central Hospital) ;
  • Sun, Gui-Yin (Department of Oncology, Jiangjin Central Hospital)
  • Published : 2012.07.31
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Abstract

Aim: The significance of the mucinous adenocarcinoma in TNM staging and prognosis for colorectal tumor patients is still controversial. The aim was to provide a meta-analysis for TNM staging and prognostic features of colorectal tumors. Methods: 30 individual case-control studies were finally included into this meta-analysis, involving a total of 444,489 cancer cases and 45,050 mucinous adenocarcinomas, of relations with TNM staging and prognostic features. Results: Compared to non-mucinous adenocarcinoma patients, the TNM IV stage accounted for a larger percentage of mucinous adenocarcinomas (OR=1.48, 95%CI 1.28-1.71, POR<0.001) and the prognosis was significantly poor (HR=1.06, 95%CI 1.04-1.08, P<0.001). After heterogeneity testing, the results was similar to the holistic approach outcome (HR=1.48, 95%CI 1.35-1.62, P<0.001). Conclusion: Compared to patients with non-mucinous adenocarcinomas, mucinous adenocarcinoma patients with later TNM staging make up a big percentage, and mucinous adenocarcinoma is an independent risk factor for poor prognosis.

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References

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