Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Relationships of uPA and VEGF Expression in Esophageal Cancer and Microvascular Density with Tumorous Invasion and Metastasis

  • Jiang, Jian-Tao (Department of Thoracic Surgery, the Second Affiliated Hospital of Medical College of XI'an Jiaotong University) ;
  • Zhang, Lan-Fang (Department of Gastroenterology, the First Affiliated Hospital of Xinxiang Medical University) ;
  • Zhou, Bin (Department of Thoracic Surgery, the Second Affiliated Hospital of Medical College of XI'an Jiaotong University) ;
  • Zhang, Shun-Qun (Department of Tumor, the Second Affiliated Hospital of Medical College of XI'an Jiaotong University) ;
  • Li, Shao-Min (Department of Thoracic Surgery, the Second Affiliated Hospital of Medical College of XI'an Jiaotong University) ;
  • Zhang, Wei (Department of Thoracic Surgery, the Second Affiliated Hospital of Medical College of XI'an Jiaotong University) ;
  • Zhang, Jin (Department of Thoracic Surgery, the Second Affiliated Hospital of Medical College of XI'an Jiaotong University) ;
  • Qiao, Zhe (Department of Thoracic Surgery, the Second Affiliated Hospital of Medical College of XI'an Jiaotong University) ;
  • Kong, Ran-Ran (Department of Thoracic Surgery, the Second Affiliated Hospital of Medical College of XI'an Jiaotong University) ;
  • Ma, Yue-Feng (Department of Thoracic Surgery, the Second Affiliated Hospital of Medical College of XI'an Jiaotong University) ;
  • Chen, Sheng (Huai'an First People's Hospital, Nanjing Medical University)
  • Published : 2012.07.31
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Abstract

Objective: To investigate uPA and VEGF expression in esophageal cancer and relations with tumorous invasion and metastasis. Methods: Immunohistochemistry was used to detect uPA and VEGF expression in the normal epithelial tissue of esophageal mucosa and cancer tissue and detect CD34 labeled micrangium and analyze the relationships with clinical pathological features and tumor angiogenesis. Results: Positive rates for uPA and VEGF protein expression were significantly greater in esophageal cancer than normal epithelial tissue (P < 0.05), the two being linked (P <0.05). In addition, uPA and VEGF protein expression of the high microvessel density (MVD) group was significantly lower than in the low MVD group (P < 0.05), with relation to clinical pathological staging, differentiation and lymph node metastasis (P < 0.05). Conclusion: In esophageal cancer tissue, uPA and VEGF proteins are overexpressed and promote tumor angiogenesis, indicative of a poor prognosis.

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