Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Glulathione-S-transferases Gene Polymorphism in Prediction of Gastric Cancer Risk by Smoking and Helicobacter Pylori Infection Status

  • Jing, Chen (Department of Cadre Ward, the General Hospital of Chengdu Military Area) ;
  • Huang, Zhi-Jie (Department of Nuclear Medicine, the General Hospital of Chengdu Military Area) ;
  • Duan, Yu-Qin (Department of Cadre Ward, the General Hospital of Chengdu Military Area) ;
  • Wang, Pei-Hong (Gastrointestinal Surgery, the General Hospital of Chengdu Military Area) ;
  • Zhang, Ru (Department of Cadre Ward, the General Hospital of Chengdu Military Area) ;
  • Luo, Ke-Shu (Department of Pathology, the General Hospital of Chengdu Military Area) ;
  • Xiao, Xin-Rong (Department of Cadre Ward, the General Hospital of Chengdu Military Area)
  • Published : 2012.07.31
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Abstract

Aim: To evaluate the association of glutathione S-transferases gene polymorphisms with the risk of gastric cancer, with reference to smoking and Helicobacter pylori infection. Methods: We conducted a 1:1 matched case-control study with 410 gastric cancer cases and 410 cancer-free controls. Polymorphisms of GSTM1, GSTT1 and GSTP1 were determined using PCR-CTPP. Results: The GSTM1 and GSTT1 null genotypes were significantly associated with the risk of gastric cancer after adjusting for potential confounding factors (OR=1.68, 95% CI=1.32-2.23 for null GSTM1, OR=1.73; 95% CI=1.24-2.13 for null GSTT1). The combination of null GSTM1 and null GSTT1 conferred an elevated risk (OR=2.54, 95% CI=1.55-3.39). However, no association was found for GSTP1 polymorphism The smoking modified the association of GSTM1 and GSTT1 null genotypes with the risk of gastric cancer. Conclusion: GSTM1 and GSTT1 null genotypes are associated with increased risk of gastric cancer, and smoking modifies the association.

Keywords

References

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