Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies

  • Wang, Xue-Jun (Department of Emergency, Taihe Hospital, Hubei University of Medicine) ;
  • Zeng, Xian-Tao (Department of Stomatology, Taihe Hospital, Hubei University of Medicine) ;
  • Duan, Xiao-Li (Department of Digestion, Taihe Hospital, Hubei University of Medicine) ;
  • Zeng, Huan-Chao (Department of Emergency, Taihe Hospital, Hubei University of Medicine) ;
  • Shen, Rui (Department of Orthopedics, Taihe Hospital, Hubei University of Medicine) ;
  • Zhou, Ping (Department of General Surgery, Taihe Hospital, Hubei University of Medicine)
  • Published : 2012.07.31
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Abstract

Objective: Experimental studies have suggested green tea to be a chemopreventive agent for colorectal cancer, and many studies have examined possible associations. However, the conclusions were inconsistent or even contradictory, so we performed a meta-analysis based on published case-control studies to explore if green tea is indeed a protective factor. Methods: PubMed was searched up to May $10^{th}$, 2012 for relevant studies, and references of included studies were manually searched. Finally 13 eligible studies, involving 12,636 cases and 38,419 controls were identified. After data extraction, a meta-analysis was performed using CMA v2 software. Results: The results indicated there may be a weak but not statistically significant reduced risk of colorectal cancer with high dose of green tea intake (OR=0.95, 95% CI:0.81-1.11, p=0.490.69-0.98). This protective effect was also found in all subgroups, except in American and European populations. Sensitivity analysis indicated the result to be robust. Publication bias was not detected by either funnel plot or Egger tests. Conclusion: The results of this meta-analysis indicate a weak lower tendency for colorectal cancer development with green tea consumption, but available epidemiologic data are insufficient to conclude that green tea may protect against colorectal cancer in humans.

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References

  1. Baron JA, Gerhardsson de Verdier M, Ekbom A (1994). Coffee, tea, tobacco, and cancer of the large bowel. Cancer Epidemiol Biomarkers Prev, 3, 565-70.
  2. Borenstein M, Hedges L, Rothstein H (2005) Comprehensive Meta-analysis. Version 2 ed. Biostat, Englewood, New Jersey.
  3. Edwards BK, Ward E, Kohler BA, et al (2010). Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer, 116, 544-73. https://doi.org/10.1002/cncr.24760
  4. Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  5. Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539-58. https://doi.org/10.1002/sim.1186
  6. Higgins JP, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
  7. Il'yasova D, Martin C, Sandler RS (2003). Tea intake and risk of colon cancer in African-Americans and whites: North Carolina colon cancer study. Cancer Causes Control, 14, 767-72. https://doi.org/10.1023/A:1026371307954
  8. Inoue M, Tajima K, Hirose K, et al (1998). Tea and coffee consumption and the risk of digestive tract cancers: data from a comparative case-referent study in Japan. Cancer Causes Control, 9, 209-16. https://doi.org/10.1023/A:1008890529261
  9. Jankun J, Selman SH, Swiercz R, et al (1997). Why drinking green tea could prevent cancer. Nature, 387, 561. https://doi.org/10.1038/42381
  10. Ji BT, Chow WH, Hsing AW, et al (1997). Green tea consumption and the risk of pancreatic and colorectal cancers. Int J Cancer, 70, 255-8. https://doi.org/10.1002/(SICI)1097-0215(19970127)70:3<255::AID-IJC1>3.0.CO;2-W
  11. Kanwar J, Taskeen M, Mohammad I, et al (2012). Recent advances on tea polyphenols. Front Biosci (Elite Ed), 4, 111-31.
  12. Kato I, Tominaga S, Matsuura A, et al (1990). A comparative case-control study of colorectal cancer and adenoma. Jpn J Cancer Res, 81, 1101-8. https://doi.org/10.1111/j.1349-7006.1990.tb02520.x
  13. Kimman M, Norman R, Jan S, et al (2012). The Burden of Cancer in Member Countries of the Association of Southeast Asian Nations (ASEAN). Asian Pac J Cancer Prev, 13, 411-20. https://doi.org/10.7314/APJCP.2012.13.2.411
  14. Li L, Zhang M, Holman D (2011). Population versus hospital controls for case-control studies on cancers in Chinese hospitals. BMC Med Res Methodol, 11, 167. https://doi.org/10.1186/1471-2288-11-167
  15. Munoz SE, Navarro A, Lantieri MJ, et al (1998). Alcohol, methylxanthine-containing beverages, and colorectal cancer in Cordoba, Argentina. Eur J Cancer Prev, 7, 207-13. https://doi.org/10.1097/00008469-199806000-00005
  16. Shimizu M, Fukutomi Y, Ninomiya M, et al (2008). Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study. Cancer Epidemiol Biomarkers Prev, 17, 3020-5. https://doi.org/10.1158/1055-9965.EPI-08-0528
  17. Siegel R, Naishadham D, Jemal A (2012). Cancer statistics, 2012. CA Cancer J Clin, 62, 10-29. https://doi.org/10.3322/caac.20138
  18. Slattery ML, Caan BJ, Anderson KE, et al (1999). Intake of fluids and methylxanthine-containing beverages: association with colon cancer. Int J Cancer, 81, 199-204. https://doi.org/10.1002/(SICI)1097-0215(19990412)81:2<199::AID-IJC6>3.0.CO;2-7
  19. Stingl JC, Ettrich T, Muche R, et al (2011). Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population. BMC Cancer, 11, 360. https://doi.org/10.1186/1471-2407-11-360
  20. Sun CL, Yuan JM, Koh WP, et al (2006). Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies. Carcinogenesis, 27, 1301-9. https://doi.org/10.1093/carcin/bgl024
  21. Sung JJ, Lau JY, Goh KL, et al (2005). Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol, 6, 871-6. https://doi.org/10.1016/S1470-2045(05)70422-8
  22. Tavani A, Pregnolato A, La Vecchia C, et al (1997). Coffee and tea intake and risk of cancers of the colon and rectum: a study of 3,530 cases and 7,057 controls. Int J Cancer, 73, 193-7. https://doi.org/10.1002/(SICI)1097-0215(19971009)73:2<193::AID-IJC5>3.0.CO;2-R
  23. Woolcott CG, King WD, Marrett LD (2002). Coffee and tea consumption and cancers of the bladder, colon and rectum. Eur J Cancer Prev, 11, 137-45. https://doi.org/10.1097/00008469-200204000-00005
  24. Wu Y, Jin M, Liu B, et al (2011). The association of XPC polymorphisms and tea drinking with colorectal cancer risk in a Chinese population. Mol Carcinog, 50, 189-98. https://doi.org/10.1002/mc.20704
  25. Yang CS, Wang H, Li GX, et al (2011). Cancer prevention by tea: Evidence from laboratory studies. Pharmacol Res, 64: 113-22. https://doi.org/10.1016/j.phrs.2011.03.001
  26. Zhang B, Li X, Nakama H, et al (2002). A case-control study on risk of changing food consumption for colorectal cancer. Cancer Invest, 20, 458-63. https://doi.org/10.1081/CNV-120002145
  27. Zhang M, Jin M, Yu Y, et al (2011). Associations of lifestyle-related factors, hsa-miR-149 and hsa-miR-605 gene polymorphisms with gastrointestinal cancer risk. Mol Carcinog, in press.

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