Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Serum Levels of Alpha-Tocopherol, Vitamin C, Beta-Carotene, and Retinol in Malignant Pleural Mesothelioma

  • Emri, Salih (Department of Chest Disease, Hacettepe University Faculty of Medicine) ;
  • Kilickap, Saadettin (Department of Medical Oncology, Cumhuriyet University Faculty of Medicine) ;
  • Kadilar, Cem (Department of Biostatistics, Hacettepe University Faculty of Medicine) ;
  • Halil, Meltem Gulhan (Department of Internal Medicine, Hacettepe University Faculty of Medicine) ;
  • Akay, Hadi (Department of Chest Surgery, Ankara University Medical Faculty) ;
  • Besler, Tanju (School of Health Technology, Hacettepe University)
  • Published : 2012.07.31
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Abstract

The aim of this study was to investigate the possible relationship between antioxidant vitamin levels and malignant pleural mesothelioma (MPM). For this purpose, we measured the serum levels of 4 antioxidant vitamins, ${\beta}$-carotene, ${\alpha}$-tocopherol, retinol, and ascorbic acid, in patients with environmentally induced MPM and in healthy controls from one tremolite village (Kureysler), the biggest erionite village (Tuzkoy) and Ankara. A total of 160 subjects were enrolled in the study, 42 (26.3%) diagnosed with MPM and 118 (73.7%) healthy subjects. A comparison was made between the MPM group and three control groups of which two were exposed and one was unexposed to mineral fibers. The study population consisted of 82 males (51%) and 78 females (49%) with a mean of age of $44.8{\pm}14$ years (range; 20-65 years). Lowest levels of ${\beta}$-carotene, ascorbic acid, and ${\alpha}$-tocopherol were found in MPM patients (MPM vs control groups combined, p<0.0001 for each antioxidant vitamin), without any relation to age or sex. There was no significant difference between the antioxidant levels of healthy controls of Tuzkoy and Ankara. In conclusion; our findings suggested an increased risk of MPM being associated with low levels of ${\alpha}$-tocopherol and ascorbic acid in patients with MPM.

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References

  1. Albelda SM, Sterman DH, Litzky LA (1998). Malignant mesothelioma and other primary pleural tumors. In: Fishman AP, Elias JA, Fishman JA, Grippi MA, Kaiser LR, Senior RM (eds). Fishman's Pulmonary Diseases and Disorders, 3rd edn. McGraw-Hill Co., New York, 1453-63.
  2. Alfonso HS, Fritschi L, De Klerk NH, et al (2006). Plasma vitamin concentrations and incidence of mesothelioma and lung cancer in individuals exposed to crocidolite at Wittenoom, Western Australia. Eur J Cancer Prev, 15, 290-4. https://doi.org/10.1097/00008469-200608000-00003
  3. Artvinli M, Baris YI (1979). Malignant mesothelioma in a small village in the Anatolian region of Turkey: an epidemiologic study. J Natl Cancer Inst, 63, 17-23.
  4. Artvinli M, Baris YI (1982). Enviromental fiber-induced pleuro-pulmonary diseases in an Anatolian village: an epidemiological study. Arch Environ Health, 37, 177-81. https://doi.org/10.1080/00039896.1982.10667559
  5. Baris YI, Saracci R, Simonato L, Skidmore JW, Artvinli M (1981). Malignant mesothelioma and radiological chest abnormalities in two villages in Central Turkey. Lancet, 1, 984-7.
  6. Baris I, Simonato L, Artvinli M, et al (1987). Epidemiological and enviromental evidence of the health effectc of exposure to fibrous erionite fibers. A four-year study in the Cappadocian region of Turkey. Int J Cancer, 39, 10-7. https://doi.org/10.1002/ijc.2910390104
  7. Carbone M, Kratzke RA, Testa JR (2002). The pathogenesis of mesothelioma. Semin Oncol, 29, 2-17. https://doi.org/10.1016/S0093-7754(02)70081-X
  8. Cook NR, Lee IM, Manson JE, Buring JE, Hennekens CH (2000). Effects of beta-carotene supplementation on cancer incidence by baseline characteristics in the Physcians' Health Study. Cancer Causes Control, 11, 617-26. https://doi.org/10.1023/A:1008995430664
  9. Coplu L, Dumortier P, Demir AU, et al (1996). An epidemiological study in an Anatolian village in Turkey environmentally exposed to tremolite asbestos. J Environ Pathol Toxicol Oncol, 15, 177-82.
  10. de Klerk NH, Musk AW, Ambrosini GL, et al (1998). Vitamin A and cancer prevention II. Comparison of the effects of retinol and beta-carotene. Int J Cancer, 75, 362-7. https://doi.org/10.1002/(SICI)1097-0215(19980130)75:3<362::AID-IJC6>3.0.CO;2-0
  11. Desai ID (1984). Vitamin E analysis methods for animal tissues. Methods Enzymol, 105, 138-47. https://doi.org/10.1016/S0076-6879(84)05019-9
  12. Emri S, Demir A, Dogan M, et al (2002). Lung diseases due to environmental exposures to erionite and asbestos in Turkey. Toxicol Lett, 127, 251-7. https://doi.org/10.1016/S0378-4274(01)00507-0
  13. Emri S, Demir AU (2004). Malignant pleural mesothelioma in Turkey, 2000-2002. Lung Cancer, 45, 17-20. https://doi.org/10.1016/j.lungcan.2004.04.009
  14. Goodman GE, Omenn GS, Thornquist MD (1993). The Carotene and Retinol Efficacy Trial (CARET) to prevent lung cancer in high-risk populations: pilot study with cigarette smokers. Cancer Epidemiol Biomarkers Prev, 2, 389-96.
  15. Heintz NH, Janssen-Heininger YM, Mossman BT (2010). Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways. Am J Respir Cell Mol Biol, 42, 133-9. https://doi.org/10.1165/rcmb.2009-0206TR
  16. Heiononen OP, Huttunen JK, Albanes D (1994). The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancer in male smokers. N Engl J Med, 330, 1029-35. https://doi.org/10.1056/NEJM199404143301501
  17. http://www.cdc.gov/tobacco/global/gats/countries/eur/fact_sheets/turkey/2009/pdfs/turkey_2009.pdf (accessed date: 18 July 2010).
  18. Johnson NF, Edwards RE, Munday DE, Rowe N, Wagner JC (1984). Pluripotential nature of mesothelioma induced by inhalation of erionite in rats. Br J Exp Pathol, 65, 377-88.
  19. Kalayci O, Besler T, Kilinc K, Sekerel BE, Saraclar Y (2000). Serum levels of antioxidant vitamins (alpha tocopherol, beta carotene, and ascorbic acid) in children with bronchial asthma. Turk J Pediatr, 42, 17-21.
  20. Lee IM, Cook NR, Manson JE, Buring JE, Hennekens CH (1999). Beta-carotene supplementation and incidence of cancer and cardiovascular disease: the women's health study. J Natl Cancer Inst, 91, 2102-6. https://doi.org/10.1093/jnci/91.24.2102
  21. Martinotti S, Ranzato E, Burlando B (2011). In vitro screening of synergistic ascorbate-drug combinations for the treatment of malignant mesothelioma. Toxicol In Vitro, 25, 1568-74. https://doi.org/10.1016/j.tiv.2011.05.023
  22. Mc Donald AD, Harper A, El Attar OA, Mc Donald JC (1970). Epidemiology of primary malignant mesothelial tumors in Canada. Cancer, 26, 914-9. https://doi.org/10.1002/1097-0142(197010)26:4<914::AID-CNCR2820260427>3.0.CO;2-H
  23. Mc Donald JC, Mc Donald AD (1977). Epidemology of mesothelioma from established incidence. Prev Med, 6, 426-46. https://doi.org/10.1016/0091-7435(77)90025-1
  24. Milano MT, Zhang H (2010). Malignant pleural mesothelioma: a population-based study of survival. J Thorac Oncol, 5, 1841-8. https://doi.org/10.1097/JTO.0b013e3181f1cf2b
  25. Mossman BT, Landesman JM (1983). Importance of oxygen free radicals in asbestos-induced injury to airway ephitelial cells. Chest, 83, 50-1. https://doi.org/10.1378/chest.83.1.50
  26. Mossman BT, Gee JBL (1989). Medical progress: Asbestos-related disease. N Engl J Med, 320, 1721-30. https://doi.org/10.1056/NEJM198906293202604
  27. Mossman BT, Bignon J, Corn M, Seaton A, Gee JBL (1990). Asbestos: Scientific developments and implications for public policy. Science, 247, 294-301. https://doi.org/10.1126/science.2153315
  28. Mossman BT, Marsh P (1989). Evidence supporting a role for active oxygen species in asbestos-induced toxicity and lung disease. Environ Health Perspect, 81, 91-4. https://doi.org/10.1289/ehp.898191
  29. Myung SK, Kim Y, Ju W, Choi HJ, Bae WK (2010). Effects of antioxidant supplements on cancer prevention: meta-analysis of randomized controlled trials. Ann Oncol, 21, 166-79. https://doi.org/10.1093/annonc/mdp286
  30. Neeld JB, Pearson WN (1963). Macro- and micromethods for the determination of serum vitamin A using trifluoroasetic acid. J Nutr, 79, 454-62.
  31. Omenn GS, Goodman GE, Thornquist MD, et al (1996). Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med, 334, 1150-5. https://doi.org/10.1056/NEJM199605023341802
  32. Poole A, Brown RC, Turner CJ, Skidmore JW, Griffiths DM (1983). In vitro genotoxic activities of fibrous erionite. Br J Cancer, 47, 697-705. https://doi.org/10.1038/bjc.1983.108
  33. Ranzato E, Biffo S, Burlando B (2011). Selective ascorbate toxicity in malignant mesothelioma: a redox Trojan mechanism. Am J Respir Cell Mol Biol, 44, 108-17. https://doi.org/10.1165/rcmb.2009-0340OC
  34. Robinson BW, Musk AW, Lake RA (2005). Malignant mesothelioma. Lancet, 366, 397-408. https://doi.org/10.1016/S0140-6736(05)67025-0
  35. Robinson C, Woo S, Walsh A, Nowak AK, Lake RA (2012). The antioxidants vitamins A and E and selenium do not reduce the incidence of asbestos-induced disease in a Mouse model of mesothelioma. Nutr Cancer, 64, 315-22. https://doi.org/10.1080/01635581.2012.649100
  36. Suzuki Y (1982). Carciogenic and fibrogenic effects of zeolites: preliminary observations. Environ Res, 27, 433-45. https://doi.org/10.1016/0013-9351(82)90098-6
  37. Wagner JC, Skidmore JW, Hill RJ, Griffiths DM (1985). Erionite exposure and mesotheliomas in rats. Br J Cancer, 51, 727-30. https://doi.org/10.1038/bjc.1985.108
  38. Yazicioglu S, Oktem K, Ilcayto R, Balci K, Sayli BS (1978). Association between malignant tumours of the lungs and pleurae and asbestosis. A retrospective study. Chest, 73, 52-6. https://doi.org/10.1378/chest.73.1.52

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