Journal of Nutrition and Health

  • 제45권5호
  • /
  • Pages.437-442
  • /
  • 2012
  • /
  • 2288-3886(pISSN)
  • /
  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지
DOI QR코드

DOI QR Code

생약복합제제가 토끼의 퇴행성관절염 개선에 미치는 영향

The effect of medicinal herb administration to arthritis induced rabbit arthritistreatment

  • 권태동 (경북대학교 레저스포츠학과) ;
  • 김기훈 (경북대학교 레저스포츠학과)
  • Kwon, Tae Dong (Department of Leisure Sport, Kyungpook National University) ;
  • Kim, Ki Hoon (Department of Leisure Sport, Kyungpook National University)
  • 투고 : 2012.09.10
  • 심사 : 2012.09.26
  • 발행 : 2012.10.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The purpose of this study was is to investigate the arthritis treatment and prevention of the effects the herbral administration to experimental animals induces arthritis 4 weeks for medicinal herbs (Scutellaria baicalensis Georgi, Acanthopanacis cortex, Achyranthis Radix). To investigate the prevention of histopathological examination and molecular biological examinations for arthritis improvement in vivo New Zealand, white rabbits were divided into a normal (Normal, n = 7), or a collagen-induced arthritis (CIA, n = 7), or a collagenase injection and medicinal herbs (SAA, n = 7). It was confirmed that induced arthritis was treated with Gross examination, and the measurement of average arthritis index (MAI) and improved arthritis by medicinal herbs. TNF-${\alpha}$ and IL-$1{\beta}$ were significantly increased in the CIA and SAA groups, compared to the normal group (p < 0.05). MMP-1 and TIMP-2 were significantly increased in the CIA, compared to the other groups (p < 0.05). MMP-1 and TIMP-2 were significantly decreased in the SAA group, compared to the CIA group (p < 0.05). As a result, Herbal administration used in this study might be able to help in the treatment of arthritis induced by inflammatory and immunosuppressive effects, that which can be expected.

키워드

참고문헌

  1. Quinn MA, Green MJ, Marzo-Ortega H, Proudman S, Karim Z, Wakefield RJ, Conaghan PG, Emery P. Prognostic factors in a large cohort of patients with early undifferentiated inflammatory arthritis after application of a structured management protocol. Arthritis Rheum 2003; 48(11): 3039-3045 https://doi.org/10.1002/art.11269
  2. Visser H, le Cessie S, Vos K, Breedveld FC, Hazes JM. How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis. Arthritis Rheum 2002; 46:(2): 357-365 https://doi.org/10.1002/art.10117
  3. Lard LR, Visser H, Speyer I, vander Horst-Bruinsma IE, Zwinderman AH, Breedveld FC, Hazes JM. Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: Comparisoncomparison of two cohorts who received different treatment strategies. Am J Med 2001; 111:(6): 446-451 https://doi.org/10.1016/S0002-9343(01)00872-5
  4. Jung SM, Schumacher HR, Kim H, Kim M, Lee SH, Pessler F. Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: Elevationelevation of prostaglandin D2 levels. Arthritis Res Ther 2007; 9:(4): R64 https://doi.org/10.1186/ar2222
  5. Park KC, Park EJ, Kim ER, Kim Y, Chung SH, Cho BW, Kim S, Jin M. Therapeutic effects of PG201, an ethanol extract from herbs, through cartilage protection on collagenase-induced arthritis in rabbits. Biochem Biophys Res Commun 2005; 331(4): 1469-1477 https://doi.org/10.1016/j.bbrc.2005.04.030
  6. Shin SS, Jin M, Jung HJ, Kim B, Jeon H, Choi JJ, Kim JM, Cho BW, Chung SH, Lee YW, Song YW, Kim S. Suppressive effects of PG201, an ethanol extract from herbs, on collagen-induced arthritis in mice. Rheumatology (Oxford) 2003; 42(5): 665-672.
  7. Gao XY, Wang DW, Li FM. Determination of ecdysterone in Achyranthes Bidentatabidentata Bl. and its activity promoting proliferation of osteoblast-like cells. Yao Xue Xue Bao 2000; 35 (11): 868-870
  8. Goldring SR, Gravallese EM. Pathogenesis of boneerosionsbone erosions in rheumatoid arthritis. Curr Opin Rheumatol 2000; 12:(3): 195-199 https://doi.org/10.1097/00002281-200005000-00006
  9. Salinardi BJ, Roush JK, Schermerhorn T, Mitchell KE. Matrix metalloproteinase and tissue inhibitor of metalloproteinase in serum and synovial fluid of osteoarthritic dogs. Vet Comp Orthop Traumatol 2006; 19(1): 49-55
  10. Giannelli G, Erriquez R, Iannone F, Marinosci F, Lapadula G, Antonaci S. MMP-2, MMP-9, TIMP-1 and TIMP-2 levels in patients with rheumatoid arthritis and psoriatic arthritis. Clin Exp Rheumatol 2004; 22(3): 335-338
  11. Huh JE, Baek YH, Kim YJ, Lee JD, Choi DY, Park DS. Protective effects of butanol fraction from Betula platyphyla var. japonica on cartilage alterations in a rabbit collagenase-induced osteoarthritis. J Ethnopharmacol 2009; 123(3): 515-521 https://doi.org/10.1016/j.jep.2008.08.028
  12. Ekenstedt KJ, Sonntag WE, Loeser RF, Lindgren BR, Carlson CS. Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints. Arthritis Rheum 2006; 54(12): 3850-3858 https://doi.org/10.1002/art.22254
  13. Bezerra MC, Carvalho JF, Prokopowitsch AS, Pereira RM. RANK, RANKL and osteoprotegerin in arthritic bone loss. Braz J Med Biol Res 2005; 38(2): 161-170 https://doi.org/10.1590/S0100-879X2005000200004
  14. Christodoulou C, Choy EH. Joint inflammation and cytokine inhibition in rheumatoid arthritis. Clin Exp Med 2006; 6(1): 13-19 https://doi.org/10.1007/s10238-006-0088-5
  15. Smolen JS, Aletaha D, Koeller M, Weisman MH, Emery P. New therapies for treatment of rheumatoid arthritis. Lancet 2007; 370:(9602): 1861-1874 https://doi.org/10.1016/S0140-6736(07)60784-3
  16. Choy E. Clinical experience with inhibition of inter-leukininterleukin- 6. Rheum CisDis Clin North Am 2004; 30(2): 405-415 https://doi.org/10.1016/j.rdc.2004.01.008
  17. Andreakos ET, Foxwell BM, Brennan FM, Maini RN, Feldmann M. Cytokines and anti-cytokine biologicals in autoimmunity: present and future. Cytokine Growth Factor Rev 2002; 13(4-5): 299-313 https://doi.org/10.1016/S1359-6101(02)00018-7
  18. Cole P, Rabasseda X. The soluble tumor necrosis factor receptor etanercept: a new strategy for the treatment of autoimmune rheumatic disease. Drugs of Today Today (Barc) 2004; 40:(4):281-324 https://doi.org/10.1358/dot.2004.40.4.820078
  19. Eijsbouts AM, Kempers MJ, van den Hoogen FH, Laan RF, Hermus AR, Ross HA, Sweep FC, van de Putte LB. Effects of naproxen and sulphasalazine or methotrexate on hypothalamic-pituitary- adrenal axis activity in patients with rheumatoid arthritis. Clin Exp Rheumatol 2011; 29(1): 35-42
  20. Francoz D, Desrochers A, Simard N, Saint Pierre Y, Fecteau G, Latouche JS, Fortin M. Relative expression of matrix metalloproteinase- 2 and -9 in synovial fluid from healthy calves and calves with experimentally induced septic arthritis. Am J Vet Res 2008; 69(8): 1022-1028 https://doi.org/10.2460/ajvr.69.8.1022
  21. Heppner KJ, Matrisian LM, Jensen RA, Rodgers WH. Expression of most matrix metalloproteinase family members in breast cancer represents a tumor -induced host response. Am J Pathol 1996; 149:(1): 273-282
  22. Murphy G. Tissue inhibitors of metalloproteinases. Genome Biol 2011; 12(11): 233 https://doi.org/10.1186/gb-2011-12-11-233
  23. Robert V, Hideaki NVisse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structurestructure, function, and biochemistry. Circ Res 2003; 92:(8): 827-839 https://doi.org/10.1161/01.RES.0000070112.80711.3D