Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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The effect of medicinal herb administration to arthritis induced rabbit arthritistreatment

생약복합제제가 토끼의 퇴행성관절염 개선에 미치는 영향

  • Kwon, Tae Dong (Department of Leisure Sport, Kyungpook National University) ;
  • Kim, Ki Hoon (Department of Leisure Sport, Kyungpook National University)
  • 권태동 (경북대학교 레저스포츠학과) ;
  • 김기훈 (경북대학교 레저스포츠학과)
  • Received : 2012.09.10
  • Accepted : 2012.09.26
  • Published : 2012.10.31
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Abstract

The purpose of this study was is to investigate the arthritis treatment and prevention of the effects the herbral administration to experimental animals induces arthritis 4 weeks for medicinal herbs (Scutellaria baicalensis Georgi, Acanthopanacis cortex, Achyranthis Radix). To investigate the prevention of histopathological examination and molecular biological examinations for arthritis improvement in vivo New Zealand, white rabbits were divided into a normal (Normal, n = 7), or a collagen-induced arthritis (CIA, n = 7), or a collagenase injection and medicinal herbs (SAA, n = 7). It was confirmed that induced arthritis was treated with Gross examination, and the measurement of average arthritis index (MAI) and improved arthritis by medicinal herbs. TNF-${\alpha}$ and IL-$1{\beta}$ were significantly increased in the CIA and SAA groups, compared to the normal group (p < 0.05). MMP-1 and TIMP-2 were significantly increased in the CIA, compared to the other groups (p < 0.05). MMP-1 and TIMP-2 were significantly decreased in the SAA group, compared to the CIA group (p < 0.05). As a result, Herbal administration used in this study might be able to help in the treatment of arthritis induced by inflammatory and immunosuppressive effects, that which can be expected.

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