Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)
- Volume 44 Issue 3
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- Pages.128-135
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- 2012
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- 1738-3544(pISSN)
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- 2288-1662(eISSN)
Association of ND4L gene 10609 mutation and hearing loss in a Korean with ESRD patients
- Kim, Eun Sook (Department of Clinical Laboratory science, Wonkwang Health Science University)
- Received : 2012.08.06
- Accepted : 2012.09.15
- Published : 2012.09.30
Abstract
The kidney and cochlea have similar physiological characteristics, specifically the active transport of fluid and electrolytes, similar effects of aminoglycosides and some immunological factors. Several mitochondrial DNA (mtDNA) defects have been identified to be associated with hearing impairment either in syndromic or nonsyndromic forms. Dialysis patients had more oxidative stress than healthy subjects and this elevated oxidative stress leads to alterations of the mtDNA. To generate a more comprehensive analysis of the relationship between mitochondrial variation and hearing loss, two SNPs of 10609, 14668 position showed nominal levels of association with hearing loss. In our result, the mean PTA values in the ESRD patients were