Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Efficacy of Aprepitant in Patients with Advanced or Recurrent Lung Cancer Receiving Moderately Emetogenic Chemotherapy

  • Uchino, Junji (Department of Respiratory Medicine, Fukuoka University Faculty of Medicine) ;
  • Hirano, Ryosuke (Department of Respiratory Medicine, Fukuoka University Faculty of Medicine) ;
  • Tashiro, Naoki (Department of Respiratory Medicine, Fukuoka University Faculty of Medicine) ;
  • Yoshida, Yuji (Department of Respiratory Medicine, Fukuoka University Faculty of Medicine) ;
  • Ushijima, Shinichiro (Department of Respiratory Medicine, Fukuoka University Faculty of Medicine) ;
  • Matsumoto, Takemasa (Department of Respiratory Medicine, Fukuoka University Faculty of Medicine) ;
  • Ohta, Keiichi (Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University) ;
  • Nakatomi, Keita (Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University) ;
  • Takayama, Koichi (Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University) ;
  • Fujita, Masaki (Department of Respiratory Medicine, Fukuoka University Faculty of Medicine) ;
  • Nakanishi, Yoichi (Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University) ;
  • Watanabe, Kentaro (Department of Respiratory Medicine, Fukuoka University Faculty of Medicine)
  • Published : 2012.08.31
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Abstract

Aims and Background: To evaluate the efficacy of a combination of aprepitant and conventional antiemetic therapy in patients with advanced or recurrent lung cancer receiving moderately emetogenic chemotherapy (MEC). Methods: Patients with advanced or recurrent lung cancer who were treated with MEC regimens at the Department of Respiratory Medicine, Fukuoka University Hospital, were included and classified into the following groups: control group (treatment: 5-HT3 receptor antagonists + dexamethasone) and aprepitant group (treatment: 5-HT3 receptor antagonists + dexamethasone + aprepitant). The presence or absence of chemotherapy-induced nausea and vomiting (CINV) was evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE) v4.0; patients with grade 1 or above were considered positive for CINV. Food intake per day, completion of planned chemotherapy, and progression-free survival (PFS) achieved by chemotherapy were investigated. Results: The complete suppression rate of nausea in the aprepitant group was significantly higher than that in the control group (p = 0.0043). Throughout the study, the food intake in the aprepitant group was greater than that in the control group, with the rate being significantly higher, in particular, on day 5 (p = 0.003). The completion rate of planned chemotherapy was also higher in the aprepitant group (p = 0.042). PFS did not differ significantly, but tended to be improved in the aprepitant group. Conclusions: The aprepitant group showed significantly higher complete suppression of nausea, food intake on day 5, and completion of planned chemotherapy than the control group.

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References

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