Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Diabetes Mellitus and Prostate Cancer Risk in Asian Countries: a Meta-analysis

  • Long, Xiang-Ju (Department of Nephrology, the First Affiliated Hospital of Tianjin Medical University) ;
  • Lin, Shan (Department of Nephrology, the First Affiliated Hospital of Tianjin Medical University) ;
  • Sun, Ya-Nan (School of Basic Medical Sciences, Tianjin Medical University) ;
  • Zheng, Zhen-Feng (Department of Nephrology, the First Affiliated Hospital of Tianjin Medical University)
  • Published : 2012.08.31
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Abstract

Background/Aims: Diabetes mellitus (DM) is widely considered to be associated with risk of cancer, but studies investigating the association between DM and prostate cancer in Asian countries have reported inconsistent findings. We examined this association by conducting a detailed meta-analysis of studies published on the subject. Methods: Cohort or case-control studies were identified by searching Pubmed, Embase and Wanfang databases through May 30, 2012. Pooled relative risk (RR) with its corresponding 95% confidence interval (95% CI) were calculated using the random-effects model. Subgroup analyses were performed by the study type. Results: Finally, we identified 7 studies (four cohort studies and three case-control studies) with a total of 1,751,274 subjects from Asians. DM was associated with an increased risk of prostate cancer in Asians (unadjusted RR= 2.82, 95% CI 1.73.4.58, P < 0.001; adjusted RR= 1.31, 95% CI 1.12.1.54, P = 0.001). Subgroup analyses by study design further confirmed an obvious association. Conclusion: Findings from this meta-analysis strongly support that diabetes is associated with an increased risk of prostate cancer in Asians.

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References

  1. Barone BB, Yeh HC, Snyder CF, et al (2008). Long-term allcause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. JAMA, 300, 2754-64. https://doi.org/10.1001/jama.2008.824
  2. Bonovas S, Filioussi K ,Tsantes A (2004). Diabetes mellitus and risk of prostate cancer: a meta-analysis. Diabetologia, 47, 1071-8.
  3. Chan JC, Malik V, Jia W, et al (2009). Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA, 301, 2129-40. https://doi.org/10.1001/jama.2009.726
  4. Chen CQ, Fang LK, Cai SR, et al (2010). Effects of diabetes mellitus on prognosis of the patients with colorectal cancer undergoing resection: a cohort study with 945 patients. Chin Med J (Engl), 123, 3084-8.
  5. Chiou WK, Hwang JS, Hsu KH, et al (2012). Diabetes mellitus increased mortality rates more in gender-specific than in nongender-specific cancer patients: a retrospective study of 149,491 patients. Exp Diabetes Res, 2012, 701643.
  6. Damber JE, Aus G (2008). Prostate cancer. Lancet, 371, 1710-21. https://doi.org/10.1016/S0140-6736(08)60729-1
  7. DerSimonian R ,Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  8. Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  9. Foulkes WD (2008). Inherited susceptibility to common cancers. N Engl J Med, 359, 2143-53. https://doi.org/10.1056/NEJMra0802968
  10. Fukushima H, Masuda H, Kawakami S, et al (2012). Effect of diabetes mellitus on high-grade prostate cancer detection among Japanese obese patients with prostate-specific antigen less than 10 ng/mL. Urology, 79, 1329-34. https://doi.org/10.1016/j.urology.2012.01.070
  11. Ganesh B, Saoba SL, Sarade MN, et al (2011). Risk factors for prostate cancer: An hospital-based case-control study from Mumbai, India. Indian J Urol, 27, 345-50. https://doi.org/10.4103/0970-1591.85438
  12. Gann PH, Hennekens CH, Ma J, et al (1996). Prospective study of sex hormone levels and risk of prostate cancer. J Natl Cancer Inst, 88, 1118-26. https://doi.org/10.1093/jnci/88.16.1118
  13. Higgins JP, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
  14. Hoffman RM (2011). Clinical practice. Screening for prostate cancer. N Engl J Med, 365, 2013-9. https://doi.org/10.1056/NEJMcp1103642
  15. Hong SK, Oh JJ, Byun SS, et al (2012). Impact of diabetes mellitus on the detection of prostate cancer via contemporary multi (>/= 12)-core prostate biopsy. Prostate, 72, 51-7. https://doi.org/10.1002/pros.21405
  16. Hsieh MC, Lee TC, Cheng SM, et al (2012). The influence of type 2 diabetes and glucose-lowering therapies on cancer risk in the taiwanese. Exp Diabetes Res, 2012, 413782.
  17. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  18. Kasper JS ,Giovannucci E (2006). A meta-analysis of diabetes mellitus and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev, 15, 2056-62. https://doi.org/10.1158/1055-9965.EPI-06-0410
  19. Lee MY, Lin KD, Hsiao PJ, et al (2012). The association of diabetes mellitus with liver, colon, lung, and prostate cancer is independent of hypertension, hyperlipidemia, and gout in Taiwanese patients. Metabolism, 61, 242-9. https://doi.org/10.1016/j.metabol.2011.06.020
  20. Li Q, Kuriyama S, Kakizaki M, et al (2010). History of diabetes mellitus and the risk of prostate cancer: the Ohsaki Cohort Study. Cancer Causes Control, 21, 1025-32. https://doi.org/10.1007/s10552-010-9530-9
  21. McGrowder DA, Jackson LA ,Crawford TV (2012). Prostate cancer and metabolic syndrome: is there a link? Asian Pac J Cancer Prev, 13, 1-13. https://doi.org/10.7314/APJCP.2012.13.1.001
  22. Mori M, Masumori N, Fukuta F, et al (2011). Weight gain and family history of prostate or breast cancers as risk factors for prostate cancer: results of a case-control study in Japan. Asian Pac J Cancer Prev, 12, 743-7.
  23. Nolan CJ, Damm P, Prentki M (2011). Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet, 378, 169-81. https://doi.org/10.1016/S0140-6736(11)60614-4
  24. Onitilo AA, Engel JM, Glurich I, et al (2012). Diabetes and cancer I: risk, survival, and implications for screening. Cancer Causes Control, 23, 967-81. https://doi.org/10.1007/s10552-012-9972-3
  25. Salazar-Martinez E, Lazcano-Ponce EC, Lira-Lira GG, et al (2000). Case-control study of diabetes, obesity, physical activity and risk of endometrial cancer among Mexican women. Cancer Causes Control, 11, 707-11. https://doi.org/10.1023/A:1008913619107
  26. Snyder CF, Stein KB, Barone BB, et al (2010). Does pre-existing diabetes affect prostate cancer prognosis? A systematic review. Prostate Cancer Prostatic Dis, 13, 58-64. https://doi.org/10.1038/pcan.2009.39
  27. Tseng CH (2011). Diabetes and risk of prostate cancer: a study using the National Health Insurance. Diabetes Care, 34, 616-21. https://doi.org/10.2337/dc10-1640
  28. Tsugane S, Inoue M (2010). Insulin resistance and cancer: epidemiological evidence. Cancer Sci, 101, 1073-9. https://doi.org/10.1111/j.1349-7006.2010.01521.x

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