Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Various Aspects, Patterns and Risk Factors in Breast Cancer Patients of Balochistan

  • Published : 2012.08.31
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Abstract

Purpose: Breast cancer is the commonest malignancy of females throughout the world with one million new cases each year. In Pakistan, the burden of breast cancer disease is high with late stage presentation being a common feature, more than half being stage III or stage IV. The objective of this study was to study various aspects, patterns and risk factors in breast cancer patients of Balochistan. Method: Present study was performed on 134 patients of breast cancer who were registered in CENAR. The patients were interviewed by providing a questionnaire. Informed consent was taken from all the patients who took part in this study after explanation of the study aims. Body mass index (BMI) was calculated andbiopsy reports were obtained from patients files. All the cases were classified with respect to age, gender, ethnic group (Baloch, Pashtoon, Punjabi, Afghani, Hazara) BMI, cancer type, cancer grade, hormonal status, side of the cancer, fertility and marital status. Results: Out of 134 patients, the most common ethnic group was Pashtoon with a total of 42 and the common age group was 41-50 years with a total of 51. Invasive ductal carcinoma (IDC) was the most common type, accounting for in 128 patients (95.5%) followed by invasive lobular carcinoma (ILC). Conclusion: Pashtoon was the most common ethnic group, IDC was common type and most of the patients had an ER/PR positive hormonal status.

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References

  1. Adedayo A, Onitilo MD, Jessica M et al, (2009). Breast cancer subtypes based on ER/PR and Her2 expression: comparison of clinicopathologic features and survival. Clinical Med & Res, 7, 4-13. https://doi.org/10.3121/cmr.2009.825
  2. Alahwal MS (2006). HER-2 positivity and correlations with other histopathologic features in Breast Cancer patients- hospital based study. J Pak Med Assoc, 56, 65-8.
  3. Ballard-Barbash R, Swanson CA (1996). Body weight: estimation of risk for breast and endometrial cancers. Am J Clin Nutr, 63, 437-41. https://doi.org/10.1093/ajcn/63.3.437
  4. Banning, Maggi, Haroon Hafeez, et al (2009). The Impact of culture and sociological and psychological issues on muslim patients with breast cancer in Pakistan. Cancer Nursing, 32, 1-8. https://doi.org/10.1097/01.NCC.0000343361.68129.36
  5. Breast cancer - UK incidence statistics, (2011).
  6. Bhurgri Y, Kayani N, Faridi N, et al (2007). Patho-epidemiology of breast cancer in Karachi '1995-1997. Asian Pac J Cancer Prev, 8, 215-20.
  7. Burke ET, Braeuning MP, McLelland R, Pisano ED, Cooper LL (1998). Paget disease of the breast: a pictorial essay. Radio Graphics, 18, 1459-64.
  8. Faiza Ahmed, Sadia Mahmud, Juanita Hatcher, et al (2006). Breast cancer risk factor knowledge among nurses in teaching hospitals of Karachi, Pakistan: a cross-sectional study. BMC Nursing, 5, 6. https://doi.org/10.1186/1472-6955-5-6
  9. Gunhan-Bilgen I, Oktay A (2006). Paget's disease of the breast: clinical, mamographic,sonographic and pathologic findings in 52 cases. Eur J Radiol, 60, 256-63. https://doi.org/10.1016/j.ejrad.2006.06.010
  10. Harold A, Oberman M D (2006). Sarcomas of the breast cancer. Cancer, 18, 1233-43.
  11. Huang Z, Hankinson SE, Colditz GA, et al (1997). Dual effects of weight and weight gainon breast cancer risk. JAMA, 278, 1407-11. https://doi.org/10.1001/jama.1997.03550170037029
  12. Hussain MM, Ansari AK, (1996). Late presentation of carcinoma breast in Pakistani women. Pak Armed Forces Med J, 46, 11-5.
  13. Kushi LH, Marilyn L, Kwan, et al (2007). Lifestyle factors and survival in women with breast cancer. J Nutr, 137, 236-4. https://doi.org/10.1093/jn/137.1.236S
  14. Ludwig J (2008) Personalized therapy of sarcomas: integration of biomarkers for improved diagnosis, prognosis, and therapy selection. Curr Oncol Rep, 10, 329-37. https://doi.org/10.1007/s11912-008-0051-6
  15. Mahmood S, Rana TF, Ahmad M (2006). Common determinants of Ca Breast-a case control study in Lahore. Ann King Edward Med Coll, 12, 227-8.
  16. McPherson K, Steel C M, Dixon J M, (2000). Breast cancer- epidemiology, risk factors and genetics. BMJ, 321, 624-8. https://doi.org/10.1136/bmj.321.7261.624
  17. Meijers-Heijboer H, Ouweland A, Klijn J, et al (2002). Low penetrance familial breast cancer susceptibility due to CHK2 1100delC in non-carriers of BRCA1 or BRCA2 mutations. Nature Genetics, 31, 55-9. https://doi.org/10.1038/ng879
  18. Mamoon N, Sharif MA, Mushtaq S, et al, (2009). Breast carcinoma over three decades in northern Pakistan - are we getting anywhere? Armed Forces Institute of Pathology, Rawalpindi, Pakistan; 59
  19. Naeem M, Khan N, Aman Z, et al (2008). Breast cancer: experience at lady reading hospital, Peshawar. J Ayub Med Coll, 20, 22-5.
  20. Patrikar A, Maimoon S, Mahore S, Akhtar MA, Wilkinson A (2007) Metaplastic carcinoma of breast (carcinosarcoma variant): a case report. Indian J Pathol Microbiol, 50, 396-8.
  21. Ramon JM, Escriba JM, Casas I, et al (1996). Age at first full term pregnancy, loctation and parity and risk of breast cancer: A case-control study in Spain, Eur J of Epibemiol, 12, 449-53. https://doi.org/10.1007/BF00143995
  22. Rauf F, Kiyani N, Bhurgni Y (2006). Metaplastic carcinoma of breast, an intriguing rarity. Asian Pac J Cancer Prev, 7, 667-71.
  23. Ries LAG, Eisner MP, Kosary CL (2003). Cancer Statistics Review, 1975-2000. Bethesda, MD: National Cancer Institute.
  24. Siddiqui M S, Kayani N, Gill M S, et al (2003). Breast Diseases: a histopathological analysis of 3279 Cases at a Tertiary Care Center in Pakistan. J Pak Med Assoc, 53, ?-?.
  25. Sohail S, Alam SN (2007) Breast cancer in Pakistan-awareness and early detection. J Coll Physicians Surg Pak, 17, 711-2
  26. T Rowan T, Chlebowski, Lewis H, et al, (2009). Breast cancer after use of estrogen plus progesterone in postmenopausal women. N Engl J Med, 360, 573-87. https://doi.org/10.1056/NEJMoa0807684
  27. Tanaka K, Imoto S, Wada N, Sakemura N, Hasebe K (2008). Invasive apocrine carcinoma of the breast: clinicopathologic features of 57 patients. Breast J, 14, 164-8. https://doi.org/10.1111/j.1524-4741.2007.00548.x
  28. World Cancer Report". (2008) International Agency for Research on Cancer. http://www.iarc.fr/en/publications/pdfs-online/wcr/2008/wcr_2008.pdf. Retrieved 2011-02-26.
  29. Yerushalmi R, Hayes M.M, Gelmon KA (2009). Breast carcinoma-rare types: review of the literature. Annals of Oncology, 20, 1763-70. https://doi.org/10.1093/annonc/mdp245
  30. Zhu K, Caulfield J, Hunter S, et al (2005). Body mass index and breast cancer risk in African American women. Ann Epidemiol, 15, 123-8. https://doi.org/10.1016/j.annepidem.2004.05.011

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