Asian Pacific Journal of Cancer Prevention

  • 제13권8호
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  • Pages.3675-3680
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Expression of Endogenous Hypoxia Markers in Vulvar Squamous Cell Carcinoma

  • Li, Yu-Zhu (Department of Integrated Traditional Chinese and Western Medicine, Qilu Hospital, Shandong University) ;
  • Li, Shu-Ling (Department of Integrated Traditional Chinese and Western Medicine, Qilu Hospital, Shandong University) ;
  • Li, Xia (Institute of Basic Medicine, Shandong Academy of Medical Science) ;
  • Wang, Li-Jie (Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University) ;
  • Wang, Jiu-Ling (Department of Integrated Traditional Chinese and Western Medicine, Qilu Hospital, Shandong University) ;
  • Xu, Jia-Wen (Department of Pathology, Provincial Hospital Affiliated to Shandong University) ;
  • Wu, Zhi-Hong (Department of Integrated Traditional Chinese and Western Medicine, Qilu Hospital, Shandong University) ;
  • Gong, Li (Department of Integrated Traditional Chinese and Western Medicine, Qilu Hospital, Shandong University) ;
  • Zhang, Xiao-Dan (Department of Integrated Traditional Chinese and Western Medicine, Qilu Hospital, Shandong University)
  • 발행 : 2012.08.31
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초록

Objective: To investigate the expression of endogenous hypoxia-related markers identified as being involved in vulvar squamous cell carcinoma (VSCC). Methods: We performed immunohistochemical staining of hypoxia-inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$), glucose transporter-1 (GLUT-1), carbonic anhydrase 9 (CA-9) and vascular endothelial growth factor (VEGF), on tissue sections of 25 VSCC patients, 10 vulvar intraepithelial neoplasia (VIN) patients and 12 healthy controls. Results: HIF-$1{\alpha}$ expression was found in all sections, with no significant difference between controls, VIN and VSCC sections (all P<0.05). Glut-1 expression was found in 25% of control, 90% of VIN and 100% of VSCC sections. A significant difference between control and VIN or VSCC was observed (all P<0.05), while no difference was found between VIN and VSCC sections (P>0.05). CA-9 expression was negative in control sections, but it was found in 30% of VIN sections and 52% of VSCC sections with strong staining. Similarly, CA-9 expression also showed obvious differences between controls and VIN or VSCC sections (all P<0.05). However, there was no significant difference between VIN and VSCC (P>0.05). There were only 25% of control sections with weak VEGF expression, while strong staining was found in about 60% of VIN sections and 25% of VSCC sections (all P<0.05). In addition, a difference was also found between VIN and VSCC sections (P<0.05). Conclusion: Expression of endogenous hypoxia markers (HIF-$1{\alpha}$, GLUT-1, CA-9 and VEGF) might be involved in the malignant progression of VSCC.

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참고문헌

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피인용 문헌

  1. Maligne Tumore der Vulva: eine Übersicht für den Dermatologen vol.165, pp.7-8, 2015, https://doi.org/10.1007/s10354-015-0354-9