Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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XRCC1 Arg399Gln Gene Polymorphism and Hepatocellular Carcinoma Risk in the Chinese Han Population: A Meta-analysis

  • Duan, Wei-Hong (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
  • Zhu, Zhen-Yu (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
  • Liu, Jun-Gui (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
  • Dong, Mao-Sheng (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
  • Chen, Jun-Zhou (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
  • Liu, Quan-Dda (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
  • Xie, Yu (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
  • Sun, Ti-Ye (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
  • Gao, Ze-Feng (Shanxi Province Tumor Hospital) ;
  • Zhou, Ning-Xin (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital)
  • Published : 2012.08.31
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Abstract

Purpose: Numerous studies have evaluated the association between XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Chinese Han population. However, the results have been inconsistent. We therefore here examined whether the XRCC1 Arg399Gln gene polymorphism confers hepatocellular carcinoma risk by conducting a meta-analysis. Methods: PubMed, Google scholar and China National Knowledge Infrastructure databases were searched for eligible articles in English and Chinese that were published before April 2012. Results: 6 studies involving 1,246 patients with hepatocellular carcinoma and 1,953 controls were included. The association between XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma in the Chinese Han population was significant under GG vs AA (OR = 1.48, 95% CI = 1.13 to 1.94). Limiting the analysis to the studies with controls in the Hardy-Weinberg equilibrium, the results were persistent and robust. Conclusions: In the Chinese Han population, the XRCC1 Arg399Gln gene polymorphism is associated with an increased hepatocellular carcinoma risk.

Keywords

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