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The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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The Use of Graphene for Regenerative Medicine

그래핀의 재생의학적 이용

  • Yoon, Jeong-Kee (School of Chemical and Biological Engineering, Seoul National University) ;
  • Kim, Byung-Soo (School of Chemical and Biological Engineering, Seoul National University)
  • 윤정기 (서울대학교 공과대학 화학생물공학부) ;
  • 김병수 (서울대학교 공과대학 화학생물공학부)
  • Received : 2012.10.06
  • Accepted : 2012.10.26
  • Published : 2012.10.31
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Abstract

Graphene is a one-atom-thick sheet composed of carbon atoms only. It has a two-dimensional honeycomb structure with $sp^2$ orbital bonding, which presents some unique properties. Due to large Young's modulus, good electrical conductivity, ability to immobilize several kinds of small molecules and proteins, and biocompatibility of graphene, it has attracted interests inits ability to enhance cell growth and differentiation, followed by recent several studies. We reviewed about the osteogenic differentiation of mesenchymal stem cells, and neurogenic differentiation of neuron stem cells, and the ectodermal and mesodermal differentiation of induced pluripotent stem cells using graphene. Graphene has not only enhanced the adhesion and proliferation of mesenchymal stem cells, but also led to the faster differentiation even without any other exogenous signals. Nonetheless, graphene has some cytotoxicities in its amount-response manner, which is critical to regenerative medicine. The cytotoxicities of graphene were compared with those of grapheneoxide and carbon nanotubes.

Keywords

References

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