DOI QR코드

DOI QR Code

다운증후군 (Down's syndrome)의 한의학적(韓醫學的) 치료(治療)에 관한 고찰(考察) - 중의학(中醫學) 저널을 중심(中心)으로 -

The Literature Study on Treatment of Down's Syndrome - Within Chinese Medical Journal -

  • 정준석 (부산대학교 한의학전문대학원) ;
  • 김기봉 (부산대학교 한의학전문대학원)
  • Jung, Jun Suk (Pusan National University School of Korean Medicine) ;
  • Kim, Ki Bong (Pusan National University School of Korean Medicine)
  • 투고 : 2012.10.26
  • 심사 : 2012.11.21
  • 발행 : 2012.11.30

초록

Objectives: Literature Study of clinical cases with Traditional Chinese Medicine (TCM) as reference for Korean medicine based treatment of juvenile patients with Down's syndrome. Methods: 4 TCM journals with the highest impact factors were searched and selected among the journals listed in www.cnki.net. The search keywords were "蒙古症", "唐氏症(産生唐氏症)", "唐氏症候群", "先天愚型", "伸舌樣痴呆", "21三体綜合徵", "三染色体症", "Down's syndrome", and "Mongolism". Accordingly, searched papers were analyzed. Results: Total 6 studies were selected: RCT(5), case report(1). Among the RCT related studies, 2 studies tested the effect of Electroacupuncture (電鍼), 1 study tested the effect of Electroacupuncture and Pharmacopuncture (藥鍼) treatment together, and 2 studies tested the effect of Electroacupuncture and Herbal Medicines (藥物) co-treatment. In all the studies, the study groups showed significantly improved intelligence quotient (IQ) in comparison with the control groups. The case report showed improvement of cognitive ability and other clinical parameters as a result of Acupuncture (鍼) and Herbal Medicines co-treatment in juvenile patients with Down's syndrome. Conclusions: Clinical studies testing the effect of TCM for the treatment of Down's syndrome have been conducted in small scales, and all the studies showed a certain level of brain function improvement of the patients in the study groups. These results implicate that the methods in Korean medicine can be highly potential treatment options for the treatment of Down's syndrome. Conduction of accurate and well-controlled studies in large scale would be required to prove the effect of Korean medicine for the treatment of patients with Down's syndrome.

키워드

참고문헌

  1. Ihm CH, Kim MH, Shin SY, Koo SH, Park JW. A case of Down syndrome with duplication of chromosome 21q22. Korean J Clin Pathol. 1999;19(4): 456-9.
  2. Thompson MW , McInnes RR. Genetics in medicine. 5th ed. Philadelphia: W.B. Sauders. 1991:119, 219-2.
  3. Gardner RJM, Sutherland GR. Chromosome abnormalities and genetic counselling, 1st ed. New York: Oxford University Press. 1989:137-43.
  4. Harry F, Grace H, Robert G, Terry W. Hensle CA, Olsson GL. The influence of paternal age on Down syndrome. J Urol. 2003;169:2275-8. https://doi.org/10.1097/01.ju.0000067958.36077.d8
  5. Serra A, Neri G. Trisomy 21: Conference report and 1990 update. Am J Med Genet. 1990;7:11-9.
  6. Lài S, Shulan J, Jin R, Zhang J. Electro-acupuncture treatment for Down's syndrome in children with auditory P300. J Tradit Chin Med. 1998;39(9):536-8.
  7. Feng S, Lai X, Jin R, Zhang J. Effect of electroacupunture on brainstem evoked potential of congential Dull-witted patients. Acupunct Res. 1998;4(2):101-5.
  8. Feng S, Lai X, Jin R, Zhang J. Effect of electroacupunture combined with acupoint injection on intelligence quotient of patients with Down's syndrome. J Guangzhou Univ Tradit Med. 2003;20(4):267-70.
  9. Zhang YM. Effect of acupuncture combined with herbal medicines on intelligence quotient and adaptive behavior quotient in infant patients with Down's Syndrome. Acupunct Res. 2006;31(3):163-5.
  10. Zhang YM. Effects of acupuncture combined with medicine on intelligence quotient and electroencephalogram in children of Mongolism. J Tradit Chin Med. 2006;47(11):828-30.
  11. Tan MJ, Zhang L. Down's syndrome case. Chin Acupunct Moxibustion. 2012;32(3):208.
  12. Ministry of Health and Welfare. Family Health Undertaking Information 2012. Ministry of Health and Welfare. 2011:218-9.
  13. Choi JS, Suh G, Han YJ, Lee SU, Bu YG, Lee SU, Shin CU, Lee NH. Congenital Anomaly Survey and Statistics. Ministry of Health and Welfare, Korea Institute for Health and Social Affairs, Korean Medical Record Association. 2009:56-60.
  14. Shin JC, Kim SJ, Park, IY, Kim SY, Kim SS, Kim A, Kim YJ, Kim JH, Yang JH, Yoon BH, Jo YG. Multicenter study for birth defects monitoring systems and correlation study between birth defects and endocrine disrupters. Korea Food Drug Admi. 2008;7:37-39.
  15. Wang YY, Wang Xinzhi. On the "Huang Di Nei Jing" entitlements conferred Thought. J Tradit. 2007;48(12):1131-3.
  16. Lijiu X, Qi C. Qi Cong treatment of refractory infertility experience. J Tradit. 2011;52(4): 342-3.
  17. Gideon S, Eberhard N. Paternal age and reproduction. Hum Reprod Update. 2010;16(1):65-79. https://doi.org/10.1093/humupd/dmp027
  18. Goodin DS, Squires KC, Starr A. Long latency event-related components of the auditory evoked potential in dementia. Brain. 1978;101:635-648. https://doi.org/10.1093/brain/101.4.635
  19. Cha KM, Shin HC. Brain-Machine Interface Using P300 Brain Wave. Mag IEEE. 2010;47(5):18-23.
  20. Jung WH, Hong HK, Nam KC, Cha EJ, Kim DW. Automated algorithm of automated auditory brainstem response for neonates. Mag IEEE. 2007;44(1):100-107.
  21. Noh HU, Lee TH, Kim NH, Kim SC, Cha EJ, Kim DW. Development of A-ABR system using a microprocessor. Mag IEEE. 2009;46(2):111-7.
  22. Lee JC, Kim DW, Lee JK, Yim MB, Park YC, Kim IH. The findings of Brainstem Auditory Evoked Potential (BAEP) and Somatosensory evoked Potential (SSEP) in Head Injury. J Korean Neurosurg Soc. 1988;17(1): 5-17.
  23. Roh SY, Park KD, Choi KG. Developmental change of brainstem auditory evoked potential in neonates. J Med Ewha. 1996;19(3):377-81. https://doi.org/10.12771/emj.1996.19.3.377
  24. Yoshinaga-Itano C, Sedey AL, Coulter DK. Language of early and later-identified children with hearing loss. Pediatr. 1998;102:1161-71. https://doi.org/10.1542/peds.102.5.1161
  25. Joint Committee on Infant Hearing. Year 2000 Position statement: Principles and guidelines for early hearing detection and intervention programs. Pediatr. 2000;106:798-817. https://doi.org/10.1542/peds.106.4.798
  26. Jeongukhanuigwadaehak Gyeongrakgyeonghyeolhak Gyojaepyeonchanwiwonhoe. Daehakgyeonghyeolhakgakron Sang 4th.. Gangwondo:Eibang Publishing Co. 2008: 511,561,581,591.
  27. Jeongukhanuigwadaehak Gyeongrakgyeonghyeolhak Gyojaepyeonchanwiwonhoe. Daehakgyeonghyeolhakgakron Ha 4th.. Gangwondo:Eibang Publishing Co. 2008:929, 940,963,967,979,1223,1262-68,1310,1312,1315.
  28. Jeongukhanuigwadaehakgongdonggyojaepyeonchanwe wonhoe. Bonchohak 2nd. Seoul : Jungumsa Co. 2011: 571-72,589-629.