Food Engineering Progress (산업식품공학)

Korean Society for Industrial Food Engineering (한국산업식품공학회)
권호 표지

Anti-tumor Effects of Codonopsis Lanceolata Extracts on Human Lung and Ovarian Cancer

산지별 더덕 추출물의 폐암 및 난소암에 대한 항암 효능

  • Cho, Young-Rak (Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University) ;
  • Kim, Soo Hyeon (Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University) ;
  • Yoon, Hyun Jae (Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University) ;
  • Hong, Sam Yeol (Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University) ;
  • Ko, Hee-Young (Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University) ;
  • Park, Eun-Hee (Department of Food Science and Biotechnology, School of Biotechnology and Bioengineering, Kangwon National University) ;
  • Kim, Myoung-Dong (Department of Food Science and Biotechnology, School of Biotechnology and Bioengineering, Kangwon National University) ;
  • Seo, Dong-Wan (Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University)
  • 조영락 (강원대학교 의생명과학대학 분자생명과학과) ;
  • 김수현 (강원대학교 의생명과학대학 분자생명과학과) ;
  • 윤현재 (강원대학교 의생명과학대학 분자생명과학과) ;
  • 홍삼열 (강원대학교 의생명과학대학 분자생명과학과) ;
  • 고희영 (강원대학교 의생명과학대학 분자생명과학과) ;
  • 박은희 (강원대학교 바이오산업공학부) ;
  • 김명동 (강원대학교 바이오산업공학부) ;
  • 서동완 (강원대학교 의생명과학대학 분자생명과학과)
  • Received : 2010.12.01
  • Accepted : 2010.12.23
  • Published : 2011.02.28
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Abstract

Codonopsis lanceolata L. (Campanulaceae) has long been used in traditional Korean medicine to treat bronchitis, cough, and inflammatory diseases, however, the efficacy of anti-tumor activities remains to be defined. In this study the effects of Codonopsis lanceolata (C. lanceolata) on proliferation, migration and adhesion in lung (A549, H1299) and ovarian cancer (SKOV-3) cells were investigated. To assess and compare the pharmacological effects and production places of C. lanceolata, the ethanolic extracts of C. lanceolata from different places in Korea (Hongseong, Yecheon, Yeongwol, Yanggu, Gangjin, and Hoengseong) were prepared. The extract from Hoengseong county did have only marginal anti-proliferative activity in all the cell lines tested, however, other extracts had little or no effect on cell proliferation. The extracts from Hongseong, Gangjin or Hoengseong county had partial anti-migratory activity in lung cancer cells, but not in ovarian cancer cells. In addition, the extract from Hoengseong county had partial anti-adhesive activity in ovarian cancer cells, however, other extracts did not affect cell adhesion in both lung and ovarian cancer cells. Taken together, these findings provide the first description of anti-tumor efficacy of C. lanceolata from different production places in Korea, and suggest that C. lanceolata from Hoengseong county may have therapeutic potential in lung and ovarian cancers.

Keywords

Acknowledgement

Supported by : 강원도 시군

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