대한기계학회논문집B (Transactions of the Korean Society of Mechanical Engineers B)

  • 제35권11호
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  • Pages.1205-1211
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  • 2011
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  • 1226-4881(pISSN)
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  • 2288-5324(eISSN)
대한기계학회 (The Korean Society of Mechanical Engineers)
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말기 심질환 환자를 위한 심실보조장치용 심박조율기의 개발

Development of a Pacemaker with a Ventricular Assist Device for End-Stage Heart Failure Patients

  • 김유석 (강원대학교 기계.메카트로닉스공학과) ;
  • 박성민 (강원대학교 의과대학 흉부외과) ;
  • 최성욱 (강원대학교 기계의용공학과)
  • Kim, Yoo-Seok (Dept. of Mechanical and Mechatronics Engineering, Kangwon Nat'l Univ.) ;
  • Park, Sung-Min (School of Medicine, Kangwon Nat'l Univ.) ;
  • Choi, Seong-Wook (Dept. of Mechanical and Biomedical Engineering, Kangwon Nat'l Univ./Medical & Bio-Material Research Center, Kangwon Nat'l Univ.)
  • 투고 : 2011.04.28
  • 심사 : 2011.08.29
  • 발행 : 2011.11.01
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초록

본 논문은 말기 심질환 환자의 생존율과 치료효과를 증대시키기 위한 심실보조장치용 심박조율기의 개발에 대한 내용이다. 심실보조장치만을 이식 받은 환자는 부정맥이 발생할 가능성을 항상 갖고 있으며 심박조율기를 동시에 적용함으로써 혈류의 체순환량을 유지하고 부정맥으로 인한 장기의 손상을 예방한다. 심박조율기의 전극과 도선은 심실보조장치의 도관을 이용하여 제작되었으며, 전극은 심실보조장치의 도관이 삽관되는 좌심실의 심첨부에 도관과 함께 이식된다. 심박조율기는 0 bpm에서부터 191.4 bpm까지 자극 빈도를 조절할 수 있으며, 60 bpm의 빈도로 자극이 가하여 질 때 0.25 J 의 에너지가 심장으로 인가된다. 심실보조장치용 심박조율기의 성능과 안정성을 검증하기 위하여 돼지를 이용한 동물실험을 수행하였다. 실험동물의 심장에 86.4 bpm, 100.2 bpm, 126.6 bpm의 자극을 순차적으로 가하였고 ECG 및 대동맥혈압의 변화 대동맥 혈류를 관찰하였다.

In this paper, we developed a pacemaker that can increase the efficacy of a left ventricular assist device (LVAD) and increase the survival rate for patients suffering end-stage heart failure. Because LVAD patients can experience arrhythmia, the pacemaker incorporated into the LVAD has the important role of sustaining sufficient blood circulation during arrhythmia. The electrode of the pacemaker is located at the apex of the left ventricle, where the VAD's inlet cannula is connected. This is efficient placement, in that the electrode can transmit electrical stimulation directly to the Purkinje fibers of the myocardium. The pacemaker can change the stimulation rate from 0 bpm to 191.4 bpm when a button is pressed on the external control module, and the pacemaker normally stimulates the heart at 60 bpm with 0.25 J of energy. We performed animal experiments to evaluate the performance and reliability of the combination of the LVAD and pacemaker. At pacemaker stimulation rates of 86.4 bpm, 100.2 bpm, 126.6 bpm, we recorded the ECGs, aortic pressures, and flow rates to analyze the heart loads.

키워드

참고문헌

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피인용 문헌

  1. Detection of Premature Ventricular Contractions on a Ventricular Electrocardiogram for Patients With Left Ventricular Assist Devices vol.38, pp.12, 2014, https://doi.org/10.1111/aor.12306