International Journal of Oral Biology

The Korean Academy of Oral Biology (대한구강생물학회)
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Protective Effects of Alpinia katsumadai Extract Against Oxidative Stress

  • Lee, Eul-Jae (Department of Oral Biochemistry and Institute of Oral Biology, College of Dentistry, Kyung Hee University) ;
  • Kim, Jeong-Hee (Department of Oral Biochemistry and Institute of Oral Biology, College of Dentistry, Kyung Hee University)
  • Received : 2011.07.05
  • Accepted : 2011.09.02
  • Published : 2011.09.30
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Abstract

In the present study, total methanol extracts prepared from Alpinia katsumadai showed significant protective effects against the oxidative stress induced by hydrogen peroxide, UV-C or ${\gamma}$-ray irradiation. These protective effects were substantially increased by treatment with 20~100 ${\mu}g$/ml of the extract. The A. katsumadai total methanol preparation was further fractionated into n-hexane, dichloromethane, ethylacetate, n-butanol and water fractions. Among these five fractions, the ethylacetate and butanol fractions of A. katsumadai showed the strongest protective effects against oxidative stress induced by UV-C and ${\gamma}$-ray irradiation. These fractions also showed high DPPH radical scavenging and lipid peroxidation inhibitory activities. In addition, both fractions displayed cell proliferation activation effects, as evidenced by significant increases in colony formation. Our current data thus suggest that the mechanisms underlying the protective effects of A. katsumadai against oxidative damage may include radical scavenging, protection against cell membrane damage and stimulation of cell proliferation.

Keywords

References

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