Journal of Radiation Protection and Research

The Korean Association for Radiation Protection (대한방사선방어학회)
권호 표지

Measurement of Tumor Dose Using Optically Stimulated Luminescence Detectors (OSLDs) and Ionization Chambers for Primary and Metastatic Lymph Node Cancers with Head and Neck: Comparison of Beam Spoiler and Bolus

광자극발광선량계와 이온함을 이용한 두경부 원발종양 및 림프절 전이성 종양의 선량 측정: 산란판과 볼루스의 비교

  • Lee, Jeong-Ok (Department of Radiotechnology, Wonkwang Health Science University) ;
  • Lee, Jae-Seung (Department of Radiation Oncology, Good Samaritan Hospital) ;
  • Jeong, Dong-Hyeok (Research center, Dongnam Inst. of Radiological and Medical Sciences)
  • 이정옥 (원광보건대학 방사선과) ;
  • 이재승 (선린의료원 방사선종양학과) ;
  • 정동혁 (동남권원자력의학원 연구센터)
  • Received : 2011.07.11
  • Accepted : 2011.08.09
  • Published : 2011.09.30
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Abstract

This study conducts cross-comparison through verification of treatment planning of using beam spoiler and bolus, according to the dose variation of different tumor bed and metastatic lymph node cancers, against ionization and optically stimulated luminescence detectors(OSLDs), in head and neck radiotherapy. Verification of treatment planning examined the feasibility of inserting detectors through simulated solid dry water slabs under identical irradiated conditions from treatment planning system to measure beam spoiler and 0.5, 1 cm bolus. In addition, two detectors were cross-compared for verification of treatment planning accuracy and reliability within ${\pm}$2%. The study found that, given a beam spoiler thickness of 0.5 cm and beam spoiler-to-skin distance of 10 cm subjected to optimal dose distribution given for metastatic lymph node cancers, the bolus low-level skin dose was less, and the tumor bed dose reduced slightly. Additionally, two detectors were cross-compared for accuracy within ${\pm}$1%. Accordingly, The use of beam spoiler was determined that reduces skin side effects and can deliver an optimal dose distribution for tumor, and to apply to future clinical studies should be performed.

본 연구는 두경부 방사선치료에서 산란판(beam spoiler)과 볼루스(bolus)를 사용함에 따라 깊이가 다른 원발종양과 림프절 전이성 종양의 선량 변화를 이온함과 광자극발광선량계(optically stimulated luminescence detectors. OSLDs)를 이용하여 치료계획검증 방법으로 교차 비교하였다. 치료계획검증은 치료계획시스템에서 얻은 동일 조사 조건을 검출기가 삽입 가능한 고체 팬텀에 모사하는 방법으로 산란판과 0.5, 1 cm 볼루스를 비교하였으며 두 선량계의 교차비교는 측정 오차가 ${\pm}$2% 미만일 때 신뢰성이 있다고 판단하였다. 연구 결과 0.5 cm 두께의 산란판과 피부간 거리가 10 cm 일 때 최적의 선량분포를 얻을 수 있었으며 볼루스에 비하여 피부선량이 작고 중심부 원발종양 선량의 감소가 작았다. 또한 두 선량계의 교차 비교는 ${\pm}$1% 이내로 유의한 결과를 보였다. 두경부 종양의 방사선치료시 산란판을 사용함으로써 피부 부작용을 줄이면서 종양에 최적의 선량분포를 달성할 수 있다고 판단되었으며 향후 임상에 적용하기 위한 연구가 시행되어야 할 것이다.

Keywords

References

  1. Barsky SH, Baker A, Siegal GP, Togo S, Liotta LA. Use of anti-basement membrane antibodies to distinguish blood vessel capillaries from lymphatic capillaries. Am. J. Surg. Phathol. 1983;7(7):667-677. https://doi.org/10.1097/00000478-198310000-00007
  2. DeVita VT, Lawrence TS, Rosenberg SA, Weinberg RA, DePinho RA. DeVita, Hellman, and Rosenberg's cancer: principles & practice of oncology. 8th ed. Philadelphia PA; Lippincott Williams & Wilkins. 2008:127-131.
  3. Clifford Chao KS. Practical Essentials of Intensity Modulated Radiation Therapy. 2nd ed. Philadelphia PA; Lippincott Williams & Wilkins. 2005:233-235.
  4. Yang DS, Choi MS, Choi JO. Nodal status of the head and neck cancer patients. J. Korean Soc. Ther. Radiol. 1997;15(4):321-330.
  5. Mendenhall WM, Villaret DB, Amdur RJ, Hinerman RW, Mancuso AA. Planned neck dissection after definitive radiotherapy for squamous cell carcinoma of the head and neck. Head Neck. 2002;24(11): 1012-1018. https://doi.org/10.1002/hed.10187
  6. Yeung AR, Liauw SL, Amdur RJ, Mancuso AA, Hinerman RW, Morris CG, Villaret DB, Werning JW, Mendenhall WM. Lymph node-positive head and neck cancer treated with definitive radiotherapy: can treatment response determine the extent of neck dissection. Cancer 2008;112(5):1076-1082. https://doi.org/10.1002/cncr.23279
  7. Dnishaw KA, Agarwal JP, Laskar SG, Gupta T, Shrivastava SK, Cruz AD. Head and neck squamous cell carcinoma: the role of post-operative adjuvant radiotherapy. J. Surg. Oncol. 2005;19(1):48-55.
  8. Lloyd S, Yu JB, Wilson LD, Decker RH. Determinants and patterns of survival in adenoid cystic carcinoma of the head and neck, including an analysis of adjuvant radiotherapy. Am. J. Clin. Oncol. 2011;34(1): 76-81. https://doi.org/10.1097/COC.0b013e3181d26d45
  9. Steel J, Stewart A, Satory P. Matching extended-SSD electron beams to multileaf collimated photon beams in the treatment of head and neck cancer. Med. Phys. 2009;36(9):4244-4249. https://doi.org/10.1118/1.3187782
  10. Mayer MN, Yoshikawa H, Moriarity L, Sidhu N. Use of a petroleum-based bolus for photon radiation therapy of distal extremities in dogs. Vet Radiol. Ultrasound 2009;50(2):235-238. https://doi.org/10.1111/j.1740-8261.2009.01523.x
  11. Lief EP, Hunt MA, Hong LX, Amols HI. Radiation therapy of large intact breasts using a beam spoiler or photons with mixed energies. Med. Dosim. 2007; 32(4):246-53. https://doi.org/10.1016/j.meddos.2007.02.002
  12. Kang SK, Cho BC, Park SH, Park HC, Bae H, Kim JO, Keall PJ, Siebers JV. Monte Carlo-based treatment planning for a spoiler system with experimental validation using plane-parallel ionization chambers. Phys. Med. Biol. 2004;49(22):5145-5155. https://doi.org/10.1088/0031-9155/49/22/009
  13. Kassaee A, Bloch P, Yorke E, Altschuler MD, Rosenthal DI. Beam spoilers versus bolus for 6 MVphoton treatment of head and neck cancers. Med. Dosim. 2000;25(3):127-131. https://doi.org/10.1016/S0958-3947(00)00038-8
  14. Niroomand-Rad A, Javedan K, Rodgers JE, Harter KW. Effects of beam spoiler on radiation dose for head and neck irradiation with 10-MV photon beam. Int. J. Radiat. Oncol. Biol. Phys. 1997;37(4):935-940. https://doi.org/10.1016/S0360-3016(96)00538-X
  15. McKenna MG, Chen XG, Altschuler MD, Bloch P. Calculation of the dose in the build-up region for high energy photon beam. Treatment planning when beam spoilers are employed. Radiother Oncol. 1995; 34(1):63-68. https://doi.org/10.1016/0167-8140(95)01504-A
  16. Lee PC, Thomason C, Glasgow GP. Characteristics of a spoiled 6-MV beam from a dual-energy linear accelerator. Med. Phys. 1993;20(3):717-721. https://doi.org/10.1118/1.597021
  17. Shiau AC, Lai PL, Liang JA, Shueng PW, Chen WL, Kuan WP. Dosimetric verification of surface and superficial doses for head and neck IMRT with different PTV shrinkage margins. Med. Phys. 2011; 38(3):1435-1443. https://doi.org/10.1118/1.3553406
  18. Aznar MC, Medin J, Hemdal B, Thilander KA, Botter-Jensen L, Mattsson S. A Monte Carlo study of the energy dependence of $Al_2O_3:C$ crystals for real-time in vivo dosimetry in mammography. Radiat. Prot. Dosimetry. 2005;114(1-3):444-449. https://doi.org/10.1093/rpd/nch560
  19. Jursinic PA. Characterization of optically stimulated luminescent dosimeters, OSLDs, for clinical dosimetric measurements. Med. Phys. 2007;34(12): 4594-4604. https://doi.org/10.1118/1.2804555
  20. Viamonte A, da Rosa LA, Buckey LA, Cherpak A, Cygler JE. Radiotherapy dosimetry using a commercial OSL system. Med. Phys. 2008;35(4): 1261- 1266. https://doi.org/10.1118/1.2841940
  21. Reft CS. The energy dependence and dose response of a commercial optically stimulated luminescent detector for kilovoltage photon, megavoltage photon, and electron, proton, and carbon beams. Med. Phys. 2009;36(5):1690-1699. https://doi.org/10.1118/1.3097283
  22. Bruce G. Haffty, Lynn D. Wilson. Handbook of radiation oncology: basic principles and clinical protocols. 1st ed. Canada; Jones & Bartlett Learning. 2009:251-342.
  23. Longobardi B, De Martin E, Fiorino C, Dell'oca I, Broggi S, Cattaneo GM, Calandrino R. Comparing 3D-CRT and inversely optimized IMRT planning for head and neck cancer: equivalence between step-and-shoot and sliding window techniques. Radiother. Oncol. 2005;77(2):148-156. https://doi.org/10.1016/j.radonc.2005.09.011
  24. IAEA. Absorbed dose determination in external beam radiotherapy. An International Code of Practice for Dosimetry Basded on Standards of Absorbed Dose to Water. Technical Reports Series No. 398. Vienna: International Atomic Energy Agency, 2000.
  25. Im IC, Yu YS, Lee JS. Measurement of Skin Dose for Rectal Cancer Patients in Radiotherapy using Optically Stimulated Luminescence Detectors (OLSDs). J. Radiat. Rrot. 2011;36(2):52-58.