Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Positively Charged Silver Nanoparticles Threaded on Carbon Nanotube for the Efficient Delivery of Negatively Charged Biomolecules

  • Park, Hyung-Seok (Department of Nanobiomedical Science & WCU Research Center, Dankook University Graduate School) ;
  • Hwang, Ji-Young (Institute of Tissue Regeneration Engineering (ITREN), Dankook University) ;
  • Shin, Ueon-Sang (Department of Nanobiomedical Science & WCU Research Center, Dankook University Graduate School) ;
  • Kim, Hae-Won (Department of Nanobiomedical Science & WCU Research Center, Dankook University Graduate School) ;
  • Gong, Myoung-Seon (Department of Nanobiomedical Science & WCU Research Center, Dankook University Graduate School)
  • Received : 2011.03.28
  • Accepted : 2011.08.05
  • Published : 2011.10.20
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Abstract

Silver nanoparticle (Ag-NPs)-immobilized and amine-functionalized carbon nanotubes (MWCNTs), MWCNT-Ag-$NH_2$, were easily prepared in order to develop an efficient delivery system of biomolecules without complicated processes of manufacture. For this, Ag-NPs-immobilized MWCNTs, MWCNT-Ag, were initially prepared in order to create large surface area to enable more efficient linkage with guest-molecules using pristine MWCNTs. The Ag-NPs on MWCNTs were further positively functionalized with 2-aminoethanthiol to allow ionic linkage with biomolecules. Ultimately, the positively charged delivery system proved to be highly effective for the binding capacity of bovine serum albumin (BSA) as a negatively charged model protein, when compared to that of lysozyme used as a positively charged model protein. The releasing profile of BSA was observed in almost linear pattern for about two weeks in a saline solution. This study demonstrated the potential usefulness of the pristine MWCNTs in conjunction with Ag-NPs for the selective delivery of many (negatively or positively) charged biomolecules including proteins and genes.

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References

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