Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Anatomical Brain Connectivity Map of Korean Children

한국 아동 집단의 구조 뇌연결지도

  • Um, Min-Hee (BK21 Project for Medical Science, Yonsei University College of Medicine) ;
  • Park, Bum-Hee (BK21 Project for Medical Science, Yonsei University College of Medicine) ;
  • Park, Hae-Jeong (BK21 Project for Medical Science, Yonsei University College of Medicine)
  • 엄민희 (연세대학교 의과대학 BK21 연세의과학사업단) ;
  • 박범희 (연세대학교 의과대학 BK21 연세의과학사업단) ;
  • 박해정 (연세대학교 의과대학 BK21 연세의과학사업단)
  • Received : 2011.04.27
  • Accepted : 2011.07.13
  • Published : 2011.08.31
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Abstract

Purpose : The purpose of this study is to establish the method generating human brain anatomical connectivity from Korean children and evaluating the network topological properties using small-world network analysis. Materials and Methods : Using diffusion tensor images (DTI) and parcellation maps of structural MRIs acquired from twelve healthy Korean children, we generated a brain structural connectivity matrix for individual. We applied one sample t-test to the connectivity maps to derive a representative anatomical connectivity for the group. By spatially normalizing the white matter bundles of participants into a template standard space, we obtained the anatomical brain network model. Network properties including clustering coefficient, characteristic path length, and global/local efficiency were also calculated. Results : We found that the structural connectivity of Korean children group preserves the small-world properties. The anatomical connectivity map obtained in this study showed that children group had higher intra-hemispheric connectivity than inter-hemispheric connectivity. We also observed that the neural connectivity of the group is high between brain stem and motorsensory areas. Conclusion : We suggested a method to examine the anatomical brain network of Korean children group. The proposed method can be used to evaluate the efficiency of anatomical brain networks in people with disease.

목적 : 본 연구의 목적은 확산텐서영상에 기반하여 한국 아동 집단의 해부학적 뇌연결성 지도를 확립하고 뇌신경망의 효율성을 평가하는 기법을 개발하는 것이다. 대상 및 방법 : 건강한 아동 12명에서 얻은 확산텐서영상과 뇌구획영상을 바탕으로 구조 연결 행렬을 구하여 집단의 구조 연결성을 평가하였다. 일표본 t-검정을 시행하여 평균적인 구조 연결성을 파악하였고 이 때 얻은 각 피험자의 백질 다발을 표준공간으로 정규화하여 집단의 해부학적 뇌연결망 지도를 확립했다. 뇌신경망의 군집정도(clustering coefficient), 평균이동거리(characteristic path length), 전체/부분 연결망 효율성(global/local efficiency) 등 연결망 속성을 계산한 후 시각화 하였다. 결과 : 연결망 측면에서 한국 아동 집단의 뇌연결성이 작은세상속성을 가짐을 밝혔다. 또한 해부학적 뇌연결망 지도를 얻었는데 대뇌 반구 내의 연결성이 높게 나타남과 뇌간과 운동/감각 영역간에 많은 신경 연결이 집중되어 있음을 확인하였다. 결론 : 한국 아동 집단의 해부학적 뇌연결망 지도를 작성하는 방법론을 제시하여 뇌를 연결성 측면에서 이해하고 발달 장애와 성인 뇌신경망의 효율성을 평가할 수 있는 기본 도구를 확립하게되었다.

Keywords

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