Genomics & Informatics

Korea Genome Organization (한국유전체학회)
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A Visualization Tool for Computational Analysis of DNA Methylation Level Using Bisulfite Sequencing Data

  • Tae, Hong-Seok (Virginia Bioinformatics Institute, The Center for Genomics and Bioinformatics, Indiana University)
  • Accepted : 2011.08.29
  • Published : 2011.09.30
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Abstract

Methylation of cytosine is a post-synthesis modification that does not affect the primary DNA sequence but greatly influences gene expression level and phenotypes of an organism. As high-throughput sequencing of bisulfite-treated DNA is the most efficient method to identify methylated sites, several tools to map sequencing reads on a reference are available. But tools to visualize and to interpret the methylation level of methylation sites are currently insufficient. Herein, we present a novel tool to visualize the methylation level of CpG sites.

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References

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