Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Relationship between White Matter Changes and Cognitive Dysfunction in the Elderly with Subjective Memory Complaint

주관적 기억감퇴를 가진 노인에서 백질 변화와 인지기능 장애의 관련성

  • 신은영 (순천향대학교부속 부천병원 정신과) ;
  • 정한용 (순천향대학교부속 부천병원 정신과) ;
  • 김양래 (김양래 휴 신경정신과) ;
  • 이소영 (순천향대학교부속 부천병원 정신과) ;
  • 김신겸 (순천향대학교부속 부천병원 정신과)
  • Received : 2010.08.04
  • Accepted : 2011.06.24
  • Published : 2011.08.31
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Abstract

Objectives The purpose of this study is to evaluate the relationship between the severity of white matter changes (WMC), risk factors and cognitive domains, including executive function profiles. Method Forty nine subjects over 55 years with subjective memory complaints were assessed with MRI and neuropsychological tests. The WMC were assessed by MRI T2-FLAIR images and divided into 3 groups of mild vs. moderate vs. severe and 2 groups of mild-moderate vs. severe by using Mantyla's criteria and Fazeka's criteria. The risk factors were examined in hypertension, heart disease history and chemistry Lab. Medical conditions which affect to cognitive dysfunction and definite dementia were also excluded. Results Comparing 3 groups, hypertension was identified as a risk factor of the WMC. Comparing 2 groups, total cholesterol and LDL were identified for as the risk factor of WMC. The severity of WMC was significantly associated with cognitive disturbances and their main effect on cognition was working memory and inhibition. Conclusion The risk factors of the WMC in the elderly were hypertension, hyperlipidemia. The severity of WMC appears to be associated with executive dysfunction in the elderly.

Keywords

References

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