Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Inhibition of Aldose Reductase on Rat Lens by Tartary Buckwheat

  • Mok, So-Youn (Department of Integrative Plant Science, Chung-Ang University) ;
  • Lee, Jeong-Min (Department of Integrative Plant Science, Chung-Ang University) ;
  • Kim, Hye-Min (Department of Integrative Plant Science, Chung-Ang University) ;
  • Lee, Dong-Gu (Department of Integrative Plant Science, Chung-Ang University) ;
  • Yoon, Young-Ho (Highland Agriculture Research Center, National Institute of Crop Science) ;
  • Cho, Eun-Ju (Department of Food Science and Nutrition, Pusan National University) ;
  • Lee, Sang-Hyun (Department of Integrative Plant Science, Chung-Ang University)
  • Received : 2011.02.18
  • Accepted : 2011.08.28
  • Published : 2011.09.30
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Abstract

To evaluate the potential of naturally occurring aldose reductase (AR) inhibitors from food material, MeOH extract and stepwise polarity fractions from tartary buckwheat and two common Korean buckwheat cultivars, yangjul-maemil and daesan-maemil, were tested on AR inhibition in rat lens in vitro. The EtOAc fraction from tartary buckwheat exhibited good AR inhibitory activity ($IC_{50}$ value, $8.19\;{\mu}g$/ml). A portion of the EtOAc fraction from tartary buckwheat led to the isolation of rutin by MeOH recrystalization. Rutin exhibited good AR inhibitory activity ($IC_{50}$ value, $9.28\;{\mu}M$). These results suggest that tartary buckwheat could be a useful food material in the development of a novel AR inhibitory agent against diabetic complications.

Keywords

References

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