Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Halicylindramide A Mimetics Containing Lactone Isosteres

  • Received : 2011.01.14
  • Accepted : 2011.02.08
  • Published : 2011.08.20
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Abstract

Synthesis of halicylindramide A mimetics via solid-phase peptide synthesis is described. The N-Me-Gly-Thr residues in halicyclindramide A has been replaced by N-Me-Gly-Dpr, Lys, or N-Me-Gly-allo-Thr. Solution structures of the mimetics were compared by CD spectroscopy in an aqueous buffer and in TFE.

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References

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