Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Spontaneous Nanoparticle Formation From a Fluorescent Nucleoside Analogue

  • Bang, Eun-Kyoung (Department of Chemistry, Division of IBB, Pohang University of Science and Technology) ;
  • Moon, Do-Hyun (Beamline Division, Pohang Accelerator Laboratory, Pohang University of Science and Technology) ;
  • Kim, Byeang-Hyean (Department of Chemistry, Division of IBB, Pohang University of Science and Technology)
  • Received : 2011.01.05
  • Accepted : 2011.02.07
  • Published : 2011.08.20
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Abstract

A fluorescent nucleoside analogue, $^AC$, featuring two non-complementary nucleobases linked through an ethynyl group, was synthesized. The extended ${\pi}$-conjugation imparts $^AC$ with red-shifted absorbance (relative to adenine and cytosine) and pale-blue fluorescence. It spontaneously forms nanoparticles, which exhibit considerably enhanced fluorescence, without the help of any additional stabilizing agent. The DMSO/water ratio was an important factor influencing the construction of the NPs. X-ray crystallography confirmed the structure of $^AC$; dynamic light scattering and scanning electron microscopy confirmed the existence of the nanoparticles.

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References

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