Journal of the Korean Magnetic Resonance Society (한국자기공명학회논문지)

Korean Magnetic Resonance Society (한국자기공명학회)
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3D Structure of STAM1 UIM-ubiquitin Complex Using RosettaDock

  • Lim, Jong-Soo (College of Pharmacy, Dongguk University-Seoul) ;
  • Yi, Jong-Jae (College of Pharmacy, CHA University) ;
  • Ahn, Hee-Chul (College of Pharmacy, Dongguk University-Seoul) ;
  • Rhee, Jin-Kyu (Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute) ;
  • Son, Woo-Sung (College of Pharmacy, CHA University)
  • Received : 2011.05.05
  • Accepted : 2011.05.27
  • Published : 2011.06.20
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Abstract

3D structures of STAM1 UIM-ubiquitin complex were presented to predict and analyze the interaction between UIM and ubiquitin. To generate the protein-peptide complex structure, the RosettaDock method was used with and without NMR restraints. High resolution complex structure was acquired successfully and evaluated electrostatic interaction in the protein-peptide binding with several charged residues at the binding site. From docking results, the Rosettadock method could be useful to acquire essential information of protein-protein or protein-peptide interaction with minimal biological evidences.

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References

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