방사선산업학회지 (Journal of Radiation Industry)

한국방사선산업학회 (Korean Society of Radiation Industry)
권호 표지

방사선 기술을 이용한 옻나무 수액의 피부 알러지 저감화 효과

Reduction of Skin Allergy of Rhus verniciflua Sap Utilizing Radiation Technology

  • 정일윤 (한국원자력연구원 정읍방사선과학연구소) ;
  • 박용대 (한국원자력연구원 정읍방사선과학연구소) ;
  • 진창현 (한국원자력연구원 정읍방사선과학연구소) ;
  • 최대성 (한국원자력연구원 정읍방사선과학연구소) ;
  • 변명우 (우송대학교 외식조리영양학부) ;
  • 류형원 (한국원자력연구원 정읍방사선과학연구소) ;
  • 김동용 (한국원자력연구원 정읍방사선과학연구소) ;
  • 백지영 (한국원자력연구원 정읍방사선과학연구소)
  • Jeong, Il Yun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Park, Yong Dae (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Jin, Chang Hyun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Choi, Dae Seong (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Byun, Myung-Woo (Department of Culinary Nutrition, Woosong University) ;
  • Ryu, Hyung Won (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Kim, Dong Yong (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Baek, Ji Yeong (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
  • 투고 : 2011.02.17
  • 심사 : 2011.02.22
  • 발행 : 2011.03.30

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초록

Skin contact allergy (SCA) is not life-threatening, but a large number of people have been suffered from the reactions caused by various kinds of chemicals and products. Thus, in this study, radiation technology was employed to improve the traditional herb addition method on the SCA reduction of Rhus verniciflua sap (RVS). Rhus verniciflua has traditionally been used as an herbal medicine plant, but its urushiol derivatives are known as a major allergen for the SCA. The present study was commenced to assess the allergenicity of both gamma-irradiated and non-irradiated RVS by using guinea-pig maximization test (GPMT) in order to probe the mechanism of an SCA. In the acute dermal irritation assays, non-irradiated RVS caused erythema, but the irradiated RVS did not provoke any erythema on the abdominal skin of the guinea pigs. From the result of the GPMT, urushiols, the main chemical components of RVS, were identified as an extreme skin sensitizer, and the removal of urushiols by irradiation extremely reduced the erythema. These results suggest that radiation technology is a novel method to reduce SCA through the removal of urushiols of RVS.

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과제정보

연구 과제 주관 기관 : 농림수산식품부