Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Determination of Optimal Toxic Concentration and Accumulation of Cadmium in Broiler Chicks

  • Subhan, Fazli (Department of Biotechnology, University of Malakand (Chackdara)) ;
  • Khan, Ayaz (Department of Biotechnology, University of Malakand (Chackdara)) ;
  • Wahid, Fazli (Department of Biotechnology, School of Life Sciences, Kyunpook National University) ;
  • Shehzad, Adeeb (Department of Biotechnology, School of Life Sciences, Kyunpook National University) ;
  • Jan, Amin Ullah (Department of Breeding and Genetic, Agriculture University of Peshawar)
  • Received : 2011.03.29
  • Accepted : 2011.05.02
  • Published : 2011.09.01
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Abstract

Cadmium is considered one of the most toxic, non biodegradable heavy metal for the human and animals. The purpose of the present study was to investigate the changes in biochemical parameters of blood and accumulation of cadmium in various tissue caused by various levels of dietary cadmium chloride ($CdCl_2$) in broiler chicks. $CdCl_2$ was administered through drinking water to broiler chicks. In spectral analysis, $CdCl_2$ treatment caused a significant increase in Glutamate pyruvate transaminase (GPT), creatinine and uric acid levels in all treated groups. Intriguingly, the GPT, creatinine, and uric acid levels were significantly higher at 75 mg/kg as compared to the groups treated with high doses (100, 125 and 150 mg/kg) of $CdCl_2$. Atomic Absorption Spectrophotometer (AAS) was used for the determination of Cd accumulation in kidney, liver and Breast muscles. AAS analysis revealed that Cd accumulation is increased in breast muscles as compared to liver and kidney at higher doses of Cd than 75 mg/kg.

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References

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