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Health Effects of the Chernobyl Accident

체르노빌 사고의 건강 영향

  • Jeong, Mee-Seon (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co. Ltd.) ;
  • Jin, Young-Woo (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co. Ltd.)
  • 정미선 (한국수력원자력(주) 방사선보건연구원 방사선영향연구팀) ;
  • 진영우 (한국수력원자력(주) 방사선보건연구원 방사선영향연구팀)
  • Received : 2011.08.17
  • Accepted : 2011.08.22
  • Published : 2011.08.31

Abstract

The Chernobyl accident was a terrible catastrophe for humanity. Scientists are in concurrence about an increase of thyroid cancer incidence among children, but not among adults, because even areas less contaminated by radiation have also reported an increase in the incidence of thyroid cancer. In this case, the rise might be due to a screening effect. There is no convincing evidence that the incidence of leukemia and solid cancer has increased among the exposed populations, but it still remains a controversial issue. Additionally, apparent evidence of decreased fertility and increased hereditary effects have not been observed in the general population. WHO suggested 4,000 people could have died or may die in the future among emergency workers and residents of the most contaminated areas, while Greenpeace insists there will be 93,080 victims around the world. The radiation dose due to Chernobyl was mainly low, so if its health effects are to be found, more long-term and welldesigned research will be needed.

Keywords

References

  1. http://www.tepco.co.jp/en/press/corp-com/release/ 11072917-e.html
  2. WHO. Report of the UN Chernobyl Forum Expert group "Health" (EGH): Health Effects of the Chernobyl Accident and Special Health Care Programmes. 2005.
  3. Heidenreich WF, Bogdanova TI, Jacob P, Biryukov AG, Tronko ND. Age and time patterns in thyroid cancer after the Chernobyl accidents in the Ukraine. Radiat Res. 2000; 154: 731-732.
  4. Jacob P, Kenigsberg Y, Goulko G, Buglova E, Gering F, Golovneva A, Kruk J, Demidchik E. Thyroid cancer risk in Belarus after the Chernobyl accident: comparison with external exposures. Radiat Environ Biophys. 2000; 39: 25-31. https://doi.org/10.1007/PL00007681
  5. Ron E, Lubin JH, Shore RE, Mabuchi K, Modan B, Pottern LM, et al. Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiat Res. 1995; 141: 259-77. https://doi.org/10.2307/3579003
  6. Shibata Y, Yamashita S, Masyakin VB, Panasyuk GD, Nagataki S. 15 years after Chernobyl: new evidence of thyroid cancer. Lancet. 2001; 358: 1965- 1966. https://doi.org/10.1016/S0140-6736(01)06971-9
  7. Shakhtarin VV, Tsyb AF, Stepanenko VF, Marchenko LF. Correlation between endemic iodine deficiency and radiation-induced thyroid cancer in children and adolescents. Vopr Onkol. 2002; 48: 311-317.
  8. Shakhtarin VV, Tsyb AF, Stepanenko VF, Orlov MY, Kopecky KJ, Davis S. Iodine deficiency, radiation dose, and the risk of thyroid cancer among children and adolescents in the Bryansk region of Russia following the Chernobyl power station accident. Int J Epidemiol. 2003; 32: 584-591. https://doi.org/10.1093/ije/dyg205
  9. Tronko ND, Bogdanova TI, Epstein OV, Oleynyk VA, Komissarenko IV, Rybakov SI, et al. Thyroid cancer in children and adolescents of Ukraine having been exposed as a result of the Chornobyl accident (15-year expertise of investigations). Int J Rad Med. 2002; 4: 222-232.
  10. Tronko ND, Bogdanova TI, Likhtarev IA, et al. Summary of the 15-year observation of thyroid cancer among Ukrainian children after the Chernobyl accident. In: Shibata Y, Yamashita S, Watanabe M, Tomonaga M. editors. Radiation and Humankind. Excerpta Medica. International Congress Series, Elsevier: Amsterdam; 2003. p.91-104.
  11. Davis S, Kopecky K, Stepanenko V, Rivkind N, Voilleque P, Shakhtarin V, et al. Risk of thyroid cancer in the bryansk oblast of the russian federation following the chernobyl power station accident. Radiat Res. 2004; 162: 241-248. https://doi.org/10.1667/RR3233
  12. Ivanov VK, Tsyb AF, Petrov AV, Maksioutov MA, Shilyaeva TP, Kochergina EV. Thyroid cancer incidence among liquidators of the Chernobyl accident. Absence of dependence of radiation risks on external radiation dose. Radiat Environ Biophys. 2002; 41: 195-198.
  13. Ivanov VK, Gorski AI, Maksioutov MA, Vlasov OK, Godko AM, Tsyb AF, Tirmarche M, Valenty M, Verger P. Thyroid cancer incidence among adolescents and adults in the Bryansk region of Russia following the Chernobyl accident. Health Phys. 2003; 84: 46-60. https://doi.org/10.1097/00004032-200301000-00004
  14. Cardis E, Kesminiene A, Ivanov V, Malakhova I, Shibata Y, Khrouch V, Drozdovitch V, et al. Risk of thyroid cancer after exposure to I-131 in childhood. J Natl Cancer Inst. 2005; 97: 724-732. https://doi.org/10.1093/jnci/dji129
  15. Jacob P, Bogdanova Ti, Buglova E, Chepurniy M, Demidchik Y, Gavrilin Y, Kenigsberg J, Meckbach R, Schotola C, Shinkarev S, Tronko Md, Ulanovsky A, Vavilov S, Walsh L. Thyroid cancer risk in areas of ukraine and belarus affected by the chernobyl accident. Radiat Res. 2006; 165: 1-8. https://doi.org/10.1667/RR3479.1
  16. Rahu M, Rahu K, Auvinen A, Tekkel M, Stengrevics A, Hakulinen T, Boice JD Jr, Inskip PD. 2006. Cancer risk among chernobyl cleanup workers in Estonia and Latvia, 1986-1998. Int J Cancer. 2006; 119(1): 162-168. https://doi.org/10.1002/ijc.21733
  17. Hatch M, Brenner A, Bogdanova T, Derevyanko A, Kuptsova N, Likhtarev I, Bouville A, Tereshchenko V, Kovgan L, Shpak V, Ostroumova E, Greenebaum E, Zablotska L, Ron E, Tronko M. A screening study of thyroid cancer and other thyroid diseases among individuals exposed in utero to iodine-131 from Chernobyl fallout. J Clin Endocrinol Metab. 2009; 94(3): 899-906. https://doi.org/10.1210/jc.2008-2049
  18. Yamashita S, Shibata Y, Hoshi M, Fujimura K. 2002. Chernobyl: Message for the 21st Century. Proceedings of the 6th Chernobyl Sasakawa Medical Cooperation Symposium, Moscow, Russia; 2001. p.30-31.
  19. Zablotska LB, Ron E, Rozhko AV, Hatch M, Polyanskaya ON, Brenner AV, Lubin J, Romanov GN, McConnell RJ, O'Kane P, Evseenko VV, Drozdovitch VV, Luckyanov N, Minenko VF, Bouville A, Masyakin VB. Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident. Br J Cancer. 2011; 104(1): 181-187. https://doi.org/10.1038/sj.bjc.6605967
  20. Jin YW, Jeong M, Moon K, Yang KH, Lee Bi, Back H, Lee SG, Kim CS. Health effects 20 years after the Chernobyl accident. Int J Low Radiation. 2008; 5(3): 263-270. https://doi.org/10.1504/IJLR.2008.020255
  21. Peter F. Incidence of thyroid disorders in children in Hungary. Orv Hetil. 2002; 143: 2867-2873.
  22. Ivan A, Azoicai D. Epidemiological aspects and methodological difficulties in establishing the causal relationship of Chernobyl nuclear accident with cancer. Rev Med Chir Soc Med Nat Iasi. 2002; 106: 659-664.
  23. Szybinski Z, Huszno B, Zemla B, Bandurska-Stankiewicz E, Przybylik-Mazurek E, Nowak W, Cichon S, Buziak-Bereza M, Trofimiuk M, Szybinski P. Incidence of thyroid cancer in the selected areas of iodine deficiency in Poland. J Endocrinol Invest. 2003; 26: 63-70.
  24. Gomez Segovia I, Gallowitsch HJ, Kresnik E, Kumnig G, Igerc I, Matschnig S, Stronegger WJ, Lind P. Descriptive epidemiology of thyroid carcinoma in Carinthia, Austria: 1984-2001. Thyroid. 2004; 14: 277-286. https://doi.org/10.1089/105072504323030933
  25. Verger P, Catelinois O, Tirmarche M, Cherie-Challine L, Pirard P, Colonna M, Hubert P. Thyroid cancers in France and the Chernobyl accident: risk assessment and recommendations for improving epidemiological knowledge. Health Phys. 2003; 85: 323-329. https://doi.org/10.1097/00004032-200309000-00008
  26. Niedziela M, Korman E, Breborowicz D, Trejster E, Harasymczuk J, Warzywoda M, Rolski M, Breborowicz J. A prospective study of thyroid nodular disease in children and adolescents in western Poland from 1996 to 2000 and the incidence of thyroid carcinoma relative to iodine deficiency and the Chernobyl disaster. Pediatr Blood Cancer. 2004; 42: 84- 92. https://doi.org/10.1002/pbc.10421
  27. Murbeth S, Rousarova M, Scherb H, Lengfelder E. Thyroid cancer has increased in the adult populations of countries moderately affected by Chernobyl fallout. Med Sci Monit. 2004; 10: 300-306.
  28. Roszkowska H, Gorynski P. Thyroid cancer in Poland in 1980-2000. Przegl Epidemiol. 2004; 58: 369-76.
  29. Tondel M, Hjalmarsson P, Hardell L, Carlsson G, Axelson O. Increase of regional total cancer incidence in north Sweden due to the Chernobyl accident? J Epidemiol Community Health. 2004; 58: 1011-1016. https://doi.org/10.1136/jech.2003.017988
  30. Catelinois O, Laurier D, Verger P, Rogel A, Colonna M, Ignasiak M, Hemon D, Tirmarche M. Uncertainty and sensitivity analysis in assessment of the thyroid cancer risk related to Chernobyl fallout in Eastern France. Risk Anal. 2005; 25: 243-252. https://doi.org/10.1111/j.1539-6924.2005.00586.x
  31. Petridou E, Trichopoulos D, Dessypris N, Flytzani V, Haidas S, Kalmanti M, et al. Infant leukaemia after in utero exposure to radiation from Chernobyl. Nature. 1996; 382: 352-353. https://doi.org/10.1038/382352a0
  32. Steiner M, Burkart W, Grosche B, Kaletsch U, Michaelis J. Trends in infant leukaemia in West Germany in relation to in utero exposure due to Chernobyl accident. Radiat Environ Biophys. 1998; 37: 87-93. https://doi.org/10.1007/s004110050099
  33. Ivanov EP, Tolochko GV, Shuvaeva LP, Ivanov VE, Iaroshevich RF, Becker S, Nekolla E, Kellerer AM. Infant leukemia in Belarus after the Chernobyl accident. Radiat Environ Biophys. 1998; 37: 53-55. https://doi.org/10.1007/s004110050092
  34. Parkin DM, Cardis E, Masuyer E, et al. Childhood leukaemia following the Chernobyl accident: the European Childhood Leukaemia-Lymphoma Incidence Study (ECLIS). Eur J Cancer. 1993; 29: 87- 95. https://doi.org/10.1016/0959-8049(93)90582-Z
  35. Noshchenko AG, Zamostyan PV, Bondar OY, Drozdova VD. Radiation-induced leukemia risk among those aged 0-20 at the time of the Chernobyl accident: a case-control study in the Ukraine. Int J Cancer. 2002; 99: 609-618. https://doi.org/10.1002/ijc.10406
  36. Noshchenko AG, Bondar OY, Drozdova VD. Radiation- induced leukemia among children aged 0-5 years at the time of the Chernobyl accident. Int J Cancer. 2010; 127(2): 412-426.
  37. Ivanov V. Health status and follow-up of the liquidators in Russia. In: The Radiological Consequences of the Chernobyl Accident. Proceedings of the First International Conference, Minsk, Belaruss; 1996. p.861-870.
  38. Shantyr I, Makarova NV, Saigina EB. Cancer morbidity among the emergency workers of the Chernobyl accident.. In: Low Dose of Ionizing Radiation: Biological Effect and Regulatory Control, IAEATECDOC- 976, IAEA-CN-67/115; 1997. p.366-336.
  39. Tukov A, Dzagoeva LG. Morbidity of atomic industry workers of Russia who participated in the work of liquidating the consequences of the Chernobyl accident. In: Medical Aspects of Eliminating the Consequences of the Chernobyl Accident. Moscow, SSSR, Central Scientific Research Institute; 1993; p.97-99.
  40. Ivanov VK, Gorski AI, Tsyb AF, Khait SE. Radiation risks of leukemia incidence among Russian emergency workers, 1986-1997. In: Radiation and Risk Bulletin of the National Radiation and Epidemiological Registry. Obninsk. Moscow. Capter 4: http://phys4. harvard.edu/-wilson/radiation/Si2002/ TITLE/html. 2002.
  41. Ivanov VK, Gorski AI, Tsyb AF, Khait SE. Post- Chernobyl leukemia and thyroid cancer incidence in children and adolescents in Bryansk region: an evaluation of risks. Voprosy onkologii (in Russian). 2003; 49(4): 445-449.
  42. Buzunov VN, Omelyanetz N, Strapko et al. Chernobyl NPP accident consequences cleaning up participants in Ukraine - health status epidemiologic study - main results. 1996. p.871-878 In: The Radiological Consequences of the Chernobyl Accident. Proceedings of the First International Conference, Minsk, Belarus; 1996.
  43. Konogorov AP, Ivanov VK, Chekin SY, Khait SE. A case-control analysis of leukemia in accident emergency workers of Chernobyl. J Environ Pathol Toxicol Oncol. 2000; 19: 143-151.
  44. Romanenko AY, Finch SC, Hatch M, Lubin JH, Bebeshko VG, Bazyka DA, Gudzenko N, Dyagil IS, Reiss RF, Bouville A, Chumak VV, Trotsiuk NK, Babkina NG, Belyayev Y, Masnyk I, Ron E, Howe GR, Zablotska LB. The Ukrainian-American study of leukemia and related disorders among Chornobyl cleanup workers from Ukraine: III. Radiation risks. Radiat Res. 2008; 170(6): 711-720. https://doi.org/10.1667/RR1404.1
  45. Kesminiene A, Evrard AS, Ivanov VK, Malakhova IV, Kurtinaitis J, Stengrevics A, Tekkel M, Anspaugh LR, Bouville A, Chekin S, Chumak VV, Drozdovitch V, Gapanovich V, Golovanov I, Hubert P, Illichev SV, Khait SE, Kryuchkov VP, Maceika E, Maksyoutov M, Mirkhaidarov AK, Polyakov S, Shchukina N, Tenet V, Tserakhovich TI, Tsykalo A, Tukov AR, Cardis E. Risk of hematological malignancies among Chernobyl liquidators. Radiat Res. 2008; 170(6): 721-735. https://doi.org/10.1667/RR1231.1
  46. Osechinsky IV, Martirsov AR, Zingerman BV, et al. Leukemia and lymphomas in population of Bryansk oblast after the Chernobyl accident. in: Health Consequences of the Chernobyl and other Radiological Accidents. Materials of the International Conference, WHO, Geneva, 1995.
  47. Ivanov VK, Tsyb AF, Nilova EV, Efendiev VF, Gorsky AI, Pitkevich VA, Leshakov SY, Shiryaev VI. Cancer risks in the Kaluga oblast of the Russian Federation 10 years after the Chernobyl accident. Radiat Environ Biophys. 1997; 36: 161-167. https://doi.org/10.1007/s004110050067
  48. Bebeshko VG, Bruslova EM, Klimenko VI, Dyagil IS, Drodova VD, et al. Leukemias and lymphomas in Ukraine population exposed to chronic low dose irradiation. In: Low Doses of Ionizing Radiation: Biological Effects and Regulatory Control. Contributed papers. International Conference held in Seville, Spain, November 1997 IAEA-TECDOC- 976; 1997. p.337-338.
  49. Prisyazhniuk A, Gristchenko V, Zakordonets V, Fouzik N, Slipeniuk Y, Ryzhak I. The time trends of cancer incidence in the most contaminated regions of the Ukraine before and after the Chernobyl accident. Radiat Environ Biophys. 1995; 34: 3- 6. https://doi.org/10.1007/BF01210538
  50. IARC. International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans. In: Ionizing Radiation, Part 1: X- and Gamma (y) Radiation, and Neutrons Lyon, France. 2002.
  51. Prysyazhnyuk A, et al. Cancer incidence in Ukraine after the Chernobyl accident. In Chernobyl: Message for the 21st Century. Proceedings of the Sixth Chernobyl Sasakawa Medical Cooperation Symposium. New York: Elsevier; 2002.
  52. IARC Final Technical Report. CONTRACT N : FIGH-CT-2002-00215 (under the 5th Framework Euratom Programme) GENE-RAD-INTERACT Generadiation interactions: Their Influence on Pre-menopausal Breast Cancer Risk after Chernobyl. 2005.
  53. Prysyazhnyuk A, et al. Cancer incidence in Ukraine after the Chernobyl accident. In Chernobyl: Message for the 21st Century. Proceedings of the Sixth Chernobyl Sasakawa Medical Cooperation Symposium. New york: Elsevier; 2002.
  54. Day R, Gorin MB, Eller AW. Prevalence of lens changes in Ukrainian children residing around Chernobyl. Health Phys. 1995; 68: 632-642. https://doi.org/10.1097/00004032-199505000-00002
  55. Fedirko PA, Khilinska V. YU. The state of the lens in children residing in the zone of radioactive contamination. Analysis of results of a long-term observation. Oftalmol Zh. 1998; 2: 155-158.
  56. Wong FL, Yamada M, Sasaki H, Kodama K, Hosoda Y. Effects of radiation on the longitudinal trends of total serum cholesterol levels in the atomic bomb survivors. Radiat Res. 1999; 151: 736-746. https://doi.org/10.2307/3580213
  57. Preston DL, Shimizuy, Pierce DA, Suyama A, Mabuchi K. Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997. Radiat Res. 2003; 160: 381-407. https://doi.org/10.1667/RR3049
  58. Ivanov VK, Maksioutov MA, Chekin SY, Petrov AV, Biryukov AP, Kruglova ZG, Matyash VA, Tsyb AF, Manton KG, Kravchenko JS. The risk of radiation- induced cerebrovascular disease in Chernobyl emergency workers. Health Phys. 2006; 90(3): 199- 207. https://doi.org/10.1097/01.HP.0000175835.31663.ea
  59. Buzunov VA, Strapko NP, Pirogova YEA, Krasnikova LL, Kartushin GI, Voychulene YUS, Doma shevskaya TYE. Epidemiology of non-cancer diseases among Chernobyl accident recovery operation workers. Journal of Radiation Medicine. Russian. 2001; 3: 9-25.
  60. UNSCEAR. Hereditary Effects of Radiation. United Nations Scientific Committee on the Effects of Atomic Radiation, 2001 Report to the General Assembly, with scientific annex. United Nations sales publication E.01.IX.2. United Nations, New York; 2001.
  61. Little J. The Chernobyl accident, congenital anomalies and other reproductive outcomes. Pediat. Perinatal. Epidemiol. 1993; 7: 121-151. https://doi.org/10.1111/j.1365-3016.1993.tb00388.x
  62. Lazjuk GI, Nikolayev DL, Novikova IV, Polityko AD, Khmel RD. Belarusian population radiation exposure after Chernobyl accident and congenital malformations dynamics. Int. J. Rad. Med. 1999; 1: 63-70.
  63. Lazjuk G, Verger P, Gagnire B, Kravchuk ZH, Zatsepin I, Robert E. The congenital anomalies registry in Belarus: a tool for assessing the public health impact of the Chernobyl accident. Reprod. Toxic. 2003; 17: 666.
  64. Viinamaki H, Kumpusalo E, Myllykangas M, et al. The Chernobyl accident and mental wellbeing - a population study. Acta Psychiatr Scand. 1995; 91: 396-401. https://doi.org/10.1111/j.1600-0447.1995.tb09799.x
  65. Bromet EJ, Goldgaber D, Carlson G, Panina N, Golovakha E, Gluzman Sf, Gilbert T, Gluzman D, Lyubsky S, Schwartz JE. Children's well-being 11 years after the Chornobyl catastrophe. Arch Gen Psychiatry. 2000; 57: 563-571. https://doi.org/10.1001/archpsyc.57.6.563
  66. Havenaar J, Rumyantzeva G, Kasyanenko A, Kaasjager K, Westermann A, Van Den Brink W, Van Den Bout J, Savelkoul J. Health effects of the Chernobyl disaster: illness or illness behavior? A comparative eneral health survey in two former Soviet regions. Environ Health Perspect. 1997; 105(6): 1533-1537. https://doi.org/10.1289/ehp.97105s61533
  67. Allen PT, Rumyantseva G. The contribution of social and psychological factors to relative radiation ingestion dose in two Russian towns affected by the Chernobyl NPP accident. Society for Risk Analysis (Europe); 1995.
  68. Bromet EJ, Gluzmans, Schwartz JE, Goldgaber D. Somatic symptoms in women 11 years after the Chornobyl accident: prevalence and risk factors. Environ Health Perspect. 2002; 110(4): 625-629. https://doi.org/10.1289/ehp.02110s4625
  69. Havenaar JM, De Wilde EJ, Van Den Bout J, Drottz-Sjoberg BM, Van Den Brink W. Perception of risk and subjective health among victims of the Chernobyl disaster. Soc Sci Med. 2003; 56: 569- 572. https://doi.org/10.1016/S0277-9536(02)00062-X
  70. Litcher L, Bromet EJ, Carlson G, Squires N, Goldgaber D, Panina N, Golovakha E, Gluzman S. School and neuropsychological performance of evacuated children in Kyiv 11 years after the Chornobyl disaster. J Child Psychol Psychiatry. 2000; 41: 291-299. https://doi.org/10.1111/1469-7610.00613
  71. Bar Joseph N, Reisfel DD, Tirosh E, Silman Z, Rennert G. Neurobehavioral and cognitive performances of children exposed to low-dose radiation in the Chernobyl accident: the Israeli Chernobyl Health Effects Study. Am J Epidemiol. 2004; 160: 453-459. https://doi.org/10.1093/aje/kwh231
  72. Rahu M, Tekkel M, Veidebaum T, Pukkala E, Hakulinen T, Auvinen A, Rytomaa T, Inskip PD, Boice JD JR. The Estonian study of Chernobyl cleanup workers: II. Incidence of cancer and mortality. Radiat. Res. 1997; 147: 653-657. https://doi.org/10.2307/3579632
  73. UNSCEAR. United Nations Scientific Committee on the Effects of Atomic Radiation. 2000 Report to the General Assembly, with Scientific Annexes. Volume II: Effects... New York, United Nations. 2000.
  74. Cardis E, Anspaugh L, Ivanov VK, Likhtarev IA, Mabuchi K, Okeanov AE, Prisyazhniuk AE. Estimated long term health effects of the Chernobyl accident. in: One Decade After Chernobyl. Summing up the Consequences of the Accident. Proceedings of an International Conference, Vienna, 1996. STI/PUB/1001. IAEA, Vienna; 1996. p.241- 279.
  75. ICRP. The 2007 Recommendations of the International Commission on Radiological Protection. ICRP Publication 103. Korean Version; 2007. p.59- 61.
  76. Cardis E, Hatch M. The Chernobyl accident--an epidemiological perspective. Clin Oncol (R Coll Radiol). 2011; 23(4): 251-260. https://doi.org/10.1016/j.clon.2011.01.510

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