Journal of the Korean Data and Information Science Society

The Korean Data and Information Science Society (한국데이터정보과학회)
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Meta-regression analysis for anti-diabetic effect of green tea

녹차의 항-당뇨 효과에 대한 메타회귀분석

  • Yun, A-Reum (Department of Information and Statistics, Duksung Womens University) ;
  • Choi, Ki-Heon (Department of Information and Statistics, Duksung Womens University)
  • 윤아름 (덕성여자대학교 정보통계학과) ;
  • 최기헌 (덕성여자대학교 정보통계학과)
  • Received : 2011.04.10
  • Accepted : 2011.07.04
  • Published : 2011.08.01
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Abstract

The present study was carried out to summarize the effect of green tea in the diabetic rats by meta-analysis related studies. The association measure to test effect of green tea was Hedges' standardized mean difference. In this particular fixed effect model, body weight was significantly increased. Also, blood glucose, triglycerides were significantly decreased. In this case of heterogeneous variable, random effect model was applied. In this model, body weight was significantly increased. Also, blood glucose was significantly decreased in green tea treated group. According to the Meta-regression analysis, duration of injection was not significant for variables.

본 연구는 메타분석을 이용하여 녹차를 투여한 당뇨 유발 쥐들의 체중과 혈액 내 혈당량, 총 콜레스테롤, 중성지방, 고농도지단백 콜레스테롤의 평균비교를 통해 녹차의 항-당뇨 효과에 대해 알아보고자 한다. 헤지의 표준화된 평균차에서 고정효과모형을 적용한 결과 체중은 통계적으로 유의한 증가를 보였으며, 혈액 내 혈당량과 중성지방은 통계적으로 유의한 감소를 보였다. 동질성 검정을 통해 이질성을 보인 모든 변수에 대해 랜덤효과모형을 적용시킨 결과 체중은 유의한 증가를 보였으며, 혈액 내 혈당량은 유의한 감소를 보였다. 또한 녹차의 투여기간이 변수에 영향을 미치는지 알아보기 위해 메타회귀분석을 실시한 결과 모든 변수에 대해 녹차의 투여기간이 유의하지 않았다.

Keywords

References

  1. 김선화 (2008). <당뇨쥐에서 녹차분말 첨가식이가 혈중지질 및 간지질에 미치는 영향>, 석사학위논문, 계명대학교, 대구.
  2. 박정환 (2004). <당뇨쥐에서 대동맥 콜라겐의 당화 및 산화에 미치는 녹차음용의 효과>, 석사학위논문, 전남대학교, 광주.
  3. 최기헌, 국세정 (2008). , 자유아카데미, 서울.
  4. Babu, P. V. A., Sabitha, K. E. and Shyamaladevi, C. S. (2006). Therapeutic effect of green tea extract on oxidative stress in aorta and hear of streptozotocin diabetic rats. Chemico-Biological Interactions, 162, 114-120. https://doi.org/10.1016/j.cbi.2006.04.009
  5. Egger, M. and Davey S. G. (1997). Meta-analysis: Potentials and premise. British Medical Journal, 315, 1371-1374. https://doi.org/10.1136/bmj.315.7119.1371
  6. Harbord, R. M. and Higgins, J. P. T. (2008). Meta-regression in stata. The Stata Journal, 8, 493-519.
  7. Han, H. K., Choi, S. S. and Chung H. S. (2010). Effects of camellia sinensis L. on blood glucose and cholesterol levels of normal and streptozotocin induced diabetic male rats. Journal of the Korean Tea Society, 16, 118-123.
  8. Higgins, J. P. T., Thompson, S. G., Deeks, J. and Altman, D. G. (2003). Measuring inconsistency in meta-analyses. British Medical Journal, 327, 557-560. https://doi.org/10.1136/bmj.327.7414.557
  9. Kim, J. E. and Choi, K. H. (2010). A meta analysis for anti-hyperlipidemia effect of soybeans. Journal of the Korean Data & Information Science Society, 21, 651-667.
  10. Kim, M. J. and Choi, K. H. (2010). The anti-diabetic effect of propolis using Hedges's mean difference. Journal of the Korean Data & Information Science Society, 21, 447-459.
  11. Kook, S., Han, H., Kim, G. and Choi, K. (2008). The anti-hepatotoxic effect of ginseng in rats: Metaanalysis. Journal of the Korean Data & Information Science Society, 19, 937-949.
  12. Lee, B. R., Koh, K. O. and Park, P. S. (2007). Antihyperglycemic effects of green tea extract on alloxaninduced diabetic and OLETF rats. Journal of the Korean Society of Food Science and Nutrition, 36, 696-702. https://doi.org/10.3746/jkfn.2007.36.6.696
  13. Lee, J. Y. (2008). Meta-analysis. Journal of Korean Endocrine Society, 23, 361-378. https://doi.org/10.3803/jkes.2008.23.6.361
  14. Oh, H. J., Ko, S. G. and Shin, Y. C. (2006). Antidiabetic effect of ethanol extract of lacca simica exsicccata on streptozotocin-induced diabetic rats. Korean Journal of Oriental Preventive Medical Society, 10, 75-93.
  15. Ribaldo, P. D. B., Souza. D. S., Biswas, S. K., Block, K., Lopes de Faria, J. M. and Lopes de Faria, J. B. (2009). Green tea(Camellia sinensis) attenuates nephropathy by downregulating nox4 NADPH oxidase in diabetic spontaneously hypertensive rats. The Journal of Nutrition, 139, 96-100.
  16. Sabu, M. C., Smitha, K. and Ramadasan Kuttan (2002). Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes. Journal of Ethnopharmacology, 83, 109-116. https://doi.org/10.1016/S0378-8741(02)00217-9