The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Inducible Mechanisms for Hepatotoxicity caused by Traditional Korean Medicines in a View of Toxicology

독성학적 측면에서의 한약에 의한 간독성 유발과 기전

  • Park, Yeong-Chul (GLP Center, Catholic University of Daegu, Hayang) ;
  • Park, Hae-Mo (Dept. of Preventive medicine, School of Oriental Medicine, Sangji University) ;
  • Lee, Sun-Dong (Dept. of Preventive medicine, School of Oriental Medicine, Sangji University)
  • 박영철 (대구가톨릭대학교 GLP 센터) ;
  • 박해모 (상지대학교 한의과대학 예방의학교실) ;
  • 이선동 (상지대학교 한의과대학 예방의학교실)
  • Received : 2011.04.18
  • Accepted : 2011.06.17
  • Published : 2011.07.30
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Abstract

Objectives: There has been a lot of controversy about whether Korean traditional medicines cause drug-induced hepatotoxicity or not. However, this controversy has not been examined from a scientific approach, especially in terms of toxicology. Thus, this article for traditional Korean medicine-induced hepatotoxicity was reviewed on a basis of toxicological assessment. Methods: Toxicological assessments were carried out in a view of reactive intermediates formation from biotransformation in animals based on cytochrome P450 activity inducing oxidative stress, and case reports in world-wide. Results and Conclusions: Several herbal materials used for traditional Korean medicines were identified as possible agents causing drug-induced hepatotoxicity. Most of these agents seem to produce toxic reactive intermediates caused by cytochrome P450. Oxidative stress followed by cytochrome P450 activation could also be a reason for herb-induced hepatotoxicity. Plausible prevention of herb-induced hepatotoxicity was suggested.

Keywords

References

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